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首页> 外文期刊>World Journal of Gastroenterology >Increased plasma malondialdehyde and fructosamine in anemic H pylori infected patients: Effect of treatment
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Increased plasma malondialdehyde and fructosamine in anemic H pylori infected patients: Effect of treatment

机译：贫血幽门螺杆菌感染患者血浆丙二醛和果糖胺增加：治疗效果

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AIM: To unravel the possible association of malondialdehyde (MDA) and fructosamine in anemic H pylori infected patients and to observe the alteration in MDA and fructosamine levels in these patients after treatment for one month. METHODS: Fructosamine, MDA and glucose were estimated in 22 anemic H pylori infected patients and 16 healthy controls. Hematological parameters were also evaluated in both the groups using Sysmex-K-100 automated cell counter. The H pylori infected patients were randomly divided into two groups. H pylori infected patients in Group Ⅰ received both iron supplementation and anti-H pylori therapy, while patients in Group Ⅱ received only iron supplementation. All the biochemical and hematological parameters were estimated after one month of treatment. RESULTS: In anemic H pylori infected patients, while MDA (5.41 ± 2.16 vs 2.26 ± 0.50; P < 0.05) and fructosamine (2.64 ± 0.93 vs 1.60 ± 0.35; P < 0.05) were significantly increased, iron (32.72 ± 14.93 vs 110.25 ± 26.58; P < 0.05), hemoglobin (6.9 ± 2.6 vs 12.66 ± 0.74; P < 0.05) and ferritin (28.82 ± 16.27 vs 140.43 ± 30.72; P < 0.05) levels were significantly decreased compared with the controls. With partial correlation analysis, fructosamine was found to have a significant positive correlation with MDA. In Group Ⅰ, while MDA level decreased significantly (3.11 ± 1.73 vs 5.50 ± 2.46; P < 0.05), there was a significant increase in iron (84.09 ± 29.51 vs 36.09 ± 17.81; P < 0.05), hemoglobin (10.40 ± 1.11 vs 7.42 ± 1.90; P < 0.05) and ferritin (116.91 ± 63.34 vs 30.46 ± 17.81; P < 0.05) levels after one month. There was no significant change in the levels of fructosamine in group Ⅰ after treatment. Similarly, no significant alterations were noted in the levels of MDA, fructosamine, hemoglobin or ferritin in Group Ⅱ patients after one month of treatment. CONCLUSION: An increased level of fructosamine and MDA was found in anemic H pylori infected patients. Present data supports the premise that lipid peroxides per se do play a role in the glycation of plasma proteins. Furthermore, the findings from this study indicate that treatment for both anemia and H pylori infections is required for lowering the levels of lipid peroxides in these patients.
机译：目的：探讨贫血幽门螺杆菌感染患者丙二醛（MDA）和果糖胺的可能联系，并观察治疗一个月后这些患者的丙二醛和果糖胺水平的变化。方法：估计了22例贫血幽门螺杆菌感染患者和16例健康对照者的果糖胺，MDA和葡萄糖。还使用Sysmex-K-100自动细胞计数器在两组中评估了血液学参数。幽门螺杆菌感染的患者被随机分为两组。 Ⅰ组感染幽门螺杆菌的患者同时接受铁补充和抗H幽门螺杆菌治疗，而Ⅱ组感染者仅接受铁补充。治疗一个月后评估所有生化和血液学参数。结果：在贫血幽门螺杆菌感染患者中，MDA（5.41±2.16 vs 2.26±0.50; P <0.05）和果糖胺（2.64±0.93 vs 1.60±0.35; P <0.05）显着增加，铁（32.72±14.93 vs 110.25）与对照组相比，±26.58; P <0.05），血红蛋白（6.9±2.6与12.66±0.74; P <0.05）和铁蛋白（28.82±16.27与140.43±30.72; P <0.05）水平显着降低。通过偏相关分析，发现果糖胺与MDA呈显着正相关。 Ⅰ组中MDA水平显着下降（3.11±1.73 vs 5.50±2.46; P <0.05），铁，血红蛋白（84.09±29.51 vs 36.09±17.81; P <0.05）显着增加（10.40±1.11 vs一个月后，铁蛋白水平分别为7.42±1.90; P <0.05）和铁蛋白（116.91±63.34 vs 30.46±17.81; P <0.05）治疗后Ⅰ组果糖胺水平无明显变化。同样，治疗一个月后，Ⅱ组患者的MDA，果糖胺，血红蛋白或铁蛋白水平没有明显变化。结论：贫血幽门螺杆菌感染的患者体内果糖胺和丙二醛水平升高。现有数据支持脂质过氧化物本身确实在血浆蛋白糖基化中起作用的前提。此外，这项研究的结果表明，治疗贫血和幽门螺杆菌感染都需要降低这些患者脂质过氧化物的水平。

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