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A framework for the modeling of gut blood flow regulation and postprandial hyperaemia

机译：肠道血流调节和餐后充血建模的框架

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摘要

After a meal the activity of the gut increases markedly as digestion takes place. Associated with this increase in activity is an increase in blood flow, which has been shown to be dependent on factors such as caloric content and constitution of the meal. Much qualitative work has been carried out regarding mechanisms for the presence of food in a section of gut producing increased blood flow to that section, but there are still many aspects of this process that are not fully understood. In this paper we briefly review current knowledge on several relevant areas relating to gut blood flow, focusing on quantitative data where available and highlighting areas where further research is needed. We then present new data on the effect of feeding on flow in the superior mesenteric artery. Finally, we describe a framework for combining this data to produce a single model describing the mechanisms involved in postprandial hyperaemia. For a section of the model, where appropriate data are available, preliminary results are presented.
机译：进餐后，随着消化的发生，肠道的活动显着增加。与这种活动增加相关的是血流量的增加，这已经显示出取决于诸如卡路里含量和膳食结构的因素。关于在一部分肠道中存在食物的机理进行了许多定性研究，从而导致该部分的血流量增加，但是该过程的许多方面仍未完全理解。在本文中，我们简要回顾了与肠道血流相关的几个相关领域的当前知识，重点是可获得的定量数据并突出了需要进一步研究的领域。然后，我们介绍了饲喂对肠系膜上动脉血流的影响的新数据。最后，我们描述了一个框架，用于结合这些数据以产生一个描述餐后充血所涉及机制的单一模型。对于模型的一部分，如果有适当的数据可用，将显示初步结果。

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