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首页> 外文期刊>World Journal of Gastroenterology >Celiac disease and skin: Psoriasis association
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Celiac disease and skin: Psoriasis association

机译：乳糜泻和皮肤：牛皮癣协会

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摘要

We read with great interest the recent review by Rodrigo on the celiac disease (CD). The author analyzed all aspects of CD. Contrary to common belief, this disorder is a systemic disease, rather than a pure digestive alteration. In fact, CD is associated with several diseases: skin manifestations, endocrine disorders, iron-deficiency anemia, osteoporosis, hypertransaminasemia, neurologic disorders and cancer. In the description of skin manifestations, the author reported the association between CD and dermatitis herpetiformis (DH). This condition affects about 15%-25% of patients with CD. Antibodies for CD have been detected in patients with DH. As CD and DH may be vastly different, they both share a unique intestinal sensitivity to gluten. The rash of DH is thought to be an external marker of the underlying intestinal sensitivity that is likely to be the result of molecular mimicry between the auto-antigen tissue transglutaminase resident in the gut and the skin derived epidermal transglutaminase . However, our study group has reported all CD-associated skin manifestations described in the literature, and in particular psoriasis.
机译：我们非常感兴趣地阅读了Rodrigo最近关于乳糜泻（CD）的评论。作者分析了CD的各个方面。与普遍的看法相反，这种疾病是全身性疾病，而不是单纯的消化系统疾病。实际上，CD与多种疾病有关：皮肤表现，内分泌失调，缺铁性贫血，骨质疏松症，高转氨血症，神经系统疾病和癌症。在描述皮肤表现时，作者报告了CD与疱疹样皮炎（DH）之间的关联。这种情况影响约15％-25％的CD患者。已在DH患者中检测到CD抗体。由于CD和DH可能有很大的不同，因此它们对面筋的肠道敏感性都不同。 DH的皮疹被认为是潜在的肠道敏感性的外部标记，这很可能是肠道内驻留的自身抗原组织转谷氨酰胺酶与皮肤衍生的表皮转谷氨酰胺酶之间分子模拟的结果。但是，我们的研究小组报告了文献中描述的所有与CD相关的皮肤表现，特别是牛皮癣。

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