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首页> 外文期刊>World Journal of Gastroenterology >Detection of hepatitis C virus core antigen for early diagnosis of hepatitis C virus infection in plasma donor in China
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Detection of hepatitis C virus core antigen for early diagnosis of hepatitis C virus infection in plasma donor in China

机译：检测丙型肝炎病毒核心抗原可早期诊断中国血浆供体中的丙型肝炎病毒感染

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摘要

AIM: To evaluate the efficacy of a new hepatitis C virus (HCV) core antigen assay developed in China. METHODS: After the determination of HCV infection, 49 serial samples were selected from 11 regular plasma donors in 5 different plasma stations. To compare the performance of HCV core antigen detection and HCV PCR, these samples were genotyped, and each specimen was analyzed by ELISA for the detection of HCV core antigen and by qualitative HCV PCR. RESULTS: Among all of the sequential samples, the original 13 specimens were HCV RNA-negative, and 36 samples were HCV RNA-positive. Twenty-seven samples (75%) were HCV core antigen-positive from these HCV RNA-positive specimens. Conversely, 27 samples (93.1%) were found HCV RNA-positive in HCV core antigen-positive samples. Intervals between HCV RNA and HCV core antigen-positive, as well as between HCV core antigen-positive and HCV antibody-positive were 36.0 and 32.8 d, respectively. CONCLUSION: This HCV core antigen assay, developed in China, is able to detect much of anti-HCV-negative, HCV RNA-positive preseroconversion window period (PWP) plasma donations.
机译：目的：评估在中国开发的新型丙型肝炎病毒（HCV）核心抗原测定的功效。方法：确定HCV感染后，从5个不同血浆站的11位常规血浆供体中选择了49个系列样品。为了比较HCV核心抗原检测和HCV PCR的性能，对这些样品进行了基因分型，并通过ELISA对每个标本进行了分析，以检测HCV核心抗原并通过定性HCV PCR。结果：在所有连续样本中，最初的13个样本均为HCV RNA阴性，而36个样本为HCV RNA阳性。这些HCV RNA阳性标本中有27个样本（75％）的HCV核心抗原呈阳性。相反，在HCV核心抗原阳性样本中发现HCV RNA阳性的样本为27个（93.1％）。 HCV RNA和HCV核心抗原阳性之间的间隔以及HCV核心抗原阳性和HCV抗体阳性之间的间隔分别为36.0 d和32.8 d。结论：这种在中国开发的HCV核心抗原测定法能够检测出许多抗HCV阴性，HCV RNA阳性的血清前转化窗口期（PWP）血浆捐赠。

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