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首页> 外文期刊>Journal of Global Infectious Diseases >Human Leukocyte Antigen-E Alleles are Associated with Hepatitis C Virus, Torque Teno Virus, and Toxoplasma Co-infections but are not Associated with Hepatitis B Virus, Hepatitis D Virus, and GB Virus C Co-infections in Human Immunodeficiency Virus Patients
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Human Leukocyte Antigen-E Alleles are Associated with Hepatitis C Virus, Torque Teno Virus, and Toxoplasma Co-infections but are not Associated with Hepatitis B Virus, Hepatitis D Virus, and GB Virus C Co-infections in Human Immunodeficiency Virus Patients

机译：人类白细胞抗原E等位基因与丙型肝炎病毒，扭力Teno病毒和弓形虫共感染相关，但与人类免疫缺陷病毒患者的乙型肝炎病毒，丁型肝炎病毒和GB丙型肝炎病毒共感染无关

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Context: Data regarding the distribution of Human Leukocyte Antigen (HLA)-E alleles and their association with blood-borne pathogen infections/co-infections are limited for many populations, including Indonesia. Aims: The aim of this study was to analyze the association between HLA-E allelic variants and infection with blood-borne pathogens such as hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis D virus (HDV), torque teno virus (TTV), GB virus C (GBV-C), and Toxoplasma gondii (T. gondii) in Indonesian Javanese human immunodeficiency virus (HIV) patients. Settings and Design: A total of 320 anti-HIV-positive blood samples were analyzed for HBV, HCV, HDV, TTV, GBV-C, and T. gondii infection status and its association with HLA-E allelic variants. Materials and Methods: Nucleic acid was extracted from plasma samples and used for the molecular detection of HBV DNA, HCV RNA, HDV RNA, TTV DNA, and GBV-C RNA, whereas hepatitis B surface antigen, anti-HCV, immunoglobulin M and G (IgM and IgG) anti- T. gondii were detected through serological testing. The blood samples were genotyped for HLA-E loci using a sequence-specific primer-polymerase chain reaction. Statistical Analysis Used: Either the Chi-square or Fisher's exact test was performed to analyze the frequency of HLA-E alleles and blood-borne pathogen infections in the population. Odds ratios (ORs) were calculated to measure the association between the antibodies found and the participants’ possible risk behaviors. A logistic regression analysis was used to assess the associations. Results: HLA-E*101/0101 was associated with HCV/TTV co-infection (adjusted OR [aOR]: 3.5; 95% confidence interval [CI]: 1.156-10.734; P = 0.027) and IgM/IgG anti-Toxo positivity (aOR: 27.0; 95% CI: 3.626-200.472; P = 0.001). HLA-E*103/0103 was associated with TTV co-infection (aOR: 2.7; 95% CI: 1.509-4.796; P = 0.001). Conclusions: HLA-E alleles in Indonesian Javanese HIV patients were found to be associated with HCV, TTV, and toxoplasma co-infections.
机译：背景：关于人类白细胞抗原（HLA）-E等位基因的分布及其与血源性病原体感染/共同感染的关联的数据在包括印度尼西亚在内的许多人群中都有限。目的：本研究的目的是分析HLA-E等位基因变异与感染血液的病原体（如乙型肝炎病毒（HBV），丙型肝炎病毒（HCV），丁型肝炎病毒（HDV），扭力型）之间的关联。印尼爪哇人免疫缺陷病毒（HIV）患者中感染的病毒（TTV），GB病毒C（GBV-C）和弓形虫（T. gondii）。设置和设计：共分析了320个抗HIV阳性血液样本的HBV，HCV，HDV，TTV，GBV-C和刚地弓形虫感染状况及其与HLA-E等位基因变体的关系。材料和方法：从血浆样品中提取核酸，用于分子检测HBV DNA，HCV RNA，HDV RNA，TTV DNA和GBV-C RNA，而乙肝表面抗原，抗HCV，免疫球蛋白M和G通过血清学检测（IgM和IgG）抗弓形虫。使用序列特异性引物-聚合酶链反应对血样的HLA-E基因座进行基因分型。使用的统计分析：进行卡方检验或Fisher精确检验，以分析人群中HLA-E等位基因和血源性病原体感染的频率。计算赔率（OR）来衡量发现的抗体与参与者可能的风险行为之间的关联。逻辑回归分析用于评估关联。结果：HLA-E * 101/0101与HCV / TTV合并感染（校正OR [aOR]：3.5; 95％置信区间[CI]：1.156-10.734; P = 0.027）和IgM / IgG抗毒药相关阳性（aOR：27.0; 95％CI：3.626-200.472; P = 0.001）。 HLA-E * 103/0103与TTV合并感染相关（aOR：2.7; 95％CI：1.509-4.796; P = 0.001）。结论：印度尼西亚爪哇HIV患者的HLA-E等位基因被发现与HCV，TTV和弓形体共感染有关。

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