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首页> 外文期刊>World Journal of Gastroenterology >Prevalence of IgA-antiendomysial antibody in a patient cohort with idiopathic low bone mineral density
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Prevalence of IgA-antiendomysial antibody in a patient cohort with idiopathic low bone mineral density

机译：特发性低骨矿物质密度患者队列中IgA抗内膜抗体的患病率

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AIM: To investigate the frequency of serum IgA-antiendomysial antibody positivity in patients with low bone mineral density and to assess the risk group for screening of celiac disease. METHODS: One hundred and thirty-five patients (14 male, 121 female) with idiopathic low bone mineral density were evaluated. The median age was 57.2 years (24-81). Antiendomysial antibody was determined by the immunofluorescence method using a commercial kit (INOVA Diagnostics Inc., CA, USA), which employs a 5 μm thin cryostat section of monkey esophagus as a substrate. RESULTS: Of the 135 patients evaluated, 13 were found to have positive IgA antiendomysial antibody test (9.6%) response. None of the patients had IgA deficiency. Endoscopic appearance and histological examination were normal in all of these patients. Seropositive patients had significantly lower age (48.9 ± 4.3 vs 59.2 ± 6.2, P < 0.05), higher ratio of male gender (61.5% vs 4.9%, P < 0.01) and pre-menopausal status (8.7% vs 1.3%, P < 0.01). Lumbar spine and femoral neck z-scores, but not t-scores were significantly lower in seropositive patients. Seropositive patients had lower serum 25 (OH) vitamin D, calcium and higher serum parathormone levels than seronegative patients. CONCLUSION: The screening of celiac disease in idiopathic osteoporosis should be restricted to patients without classical risk factors (younger, pre-menopausal, male gender) for osteoporosis. Bone mineral density measurements using z-scores should be considered for identifying risk groups for celiac disease.
机译：目的：探讨骨密度低的患者血清IgA-抗内膜抗体阳性率，并评估筛查腹腔疾病的危险人群。方法：对特发性低骨矿物质密度的135例患者（男14例，女121例）进行了评估。中位年龄为57.2岁（24-81岁）。使用商业试剂盒（INOVA Diagnostics Inc.，CA，USA）通过免疫荧光法确定抗内膜抗体，该试剂盒使用5μm的猴食管低温恒温器切片作为底物。结果：在所评估的135例患者中，发现13例IgA抗内膜抗体测试阳性（9.6％）。没有患者有IgA缺乏症。所有这些患者的内镜检查和组织学检查均正常。血清阳性患者的年龄显着降低（48.9±4.3 vs 59.2±6.2，P <0.05），男性比例更高（61.5％vs 4.9％，P <0.01）和绝经前状态（8.7％vs 1.3％，P <0.05）。 0.01）。在血清反应阳性患者中，腰椎和股骨颈的z评分明显低于t评分。血清阳性患者的血清25（OH）维生素D，钙水平较低，血清副甲状腺激素水平高于血清阴性患者。结论：对特发性骨质疏松症的腹腔疾病的筛查应仅限于没有骨质疏松症的经典危险因素（年轻，绝经前，男性）的患者。应该考虑使用z分数进行骨矿物质密度测量，以确定乳糜泻的危险人群。

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