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首页> 外文期刊>World Journal of Gastroenterology >Correlation analysis of liver tumor-associated genes with liver regeneration
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Correlation analysis of liver tumor-associated genes with liver regeneration

机译：肝肿瘤相关基因与肝再生的相关性分析

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AIM: To study at transcriptional level the similarities and differences of the physiological and biochemical activities between liver tumor (LT) and regenerating liver cells. METHODS: LT-associated genes and their expression changes in LT were obtained from databases and scientific articles, and their expression profiles in rat liver regeneration (LR) were detected using Rat Genome 230 2.0 array. Subsequently their expression changes in LT and LR were compared and analyzed. RESULTS: One hundred and twenty one LT-associated genes were found to be LR-associated. Thirty four genes were up-regulated, and 14 genes were down-regulated in both LT and regenerating liver; 20 genes up-regulated in LT were down-regulated in regenerating liver; 21 up-regulated genes and 16 down-regulated genes in LT were up-regulated at some time points and down-regulated at others during LR. CONCLUSION: Results suggested that apoptosis activity suppressed in LT was still active in regenerating liver, and there are lots of similarities and differences between the LT and regenerating liver at the aspects of cell growth, proliferation, differentiation, migration and angiogenesis.
机译：目的：在转录水平上研究肝肿瘤（LT）和再生肝细胞之间的生理和生化活性的异同。方法：从数据库和科学文献中获得与LT相关的基因及其在LT中的表达变化，并使用Rat Genome 230 2.0阵列检测其在大鼠肝再生（LR）中的表达谱。随后比较并分析了它们在LT和LR中的表达变化。结果：共发现121个LT相关基因与LR相关。在LT和再生肝中有34个基因被上调，而14个基因被下调。 LT中上调的20个基因在再生肝中下调；在LR期间，LT中的21个上调基因和16个下调基因在某些时间点上调而在其他时间点下调。结论：LT抑制的细胞凋亡活性在再生肝中仍然活跃，并且LT与再生肝在细胞生长，增殖，分化，迁移和血管生成等方面有很多相似之处和不同之处。

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