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首页> 外文期刊>World Journal of Gastroenterology >Functional brain imaging of gastrointestinal sensation in health and disease
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Functional brain imaging of gastrointestinal sensation in health and disease

机译：健康和疾病中胃肠道感觉的功能性脑成像

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It has since long been known, from everyday experience as well as from animal and human studies, that psychological processes-both affective and cognitive-exert an influence on gastrointestinal sensorimotor function. More specifically, a link between psychological factors and visceral hypersensitivity has been suggested, mainly based on research in functional gastrointestinal disorder patients. However, until recently, the exact nature of this putative relationship remained unclear, mainly due to a lack of non-invasive methods to study the (neurobiological) mechanisms underlying this relationship in non-sleeping humans. As functional brain imaging, introduced in visceral sensory neuroscience some 10 years ago, does provide a method for in vivo study of brain-gut interactions, insight into the neurobiological mechanisms underlying visceral sensation in general and the influence of psychological factors more particularly, has rapidly grown. In this article, an overview of brain imaging evidence on gastrointestinal sensation will be given, with special emphasis on the brain mechanisms underlying the interaction between affective & cognitive processes and visceral sensation. First, the reciprocal neural pathways between the brain and the gut (brain-gut axis) will be briefly outlined, including brain imaging evidence in healthy volunteers. Second, functional brain imaging studies assessing the influence of psychological factors on brain processing of visceral sensation in healthy humans will be discussed in more detail. Finally, brain imaging work investigating differences in brain responses to visceral distension between healthy volunteers and functional gastrointestinal disorder patients will be highlighted.
机译：长期以来，从日常经验以及动物和人类研究中已经知道，心理过程（情感和认知过程）都会对胃肠道感觉运动功能产生影响。更具体地，已经提出了心理因素与内脏超敏反应之间的联系，这主要基于功能性胃肠疾病患者的研究。然而，直到最近，这种推测关系的确切性质仍不清楚，这主要是由于缺乏非侵入性方法来研究非睡眠人类这种关系基础的（神经生物学）机制。大约10年前在内脏感觉神经科学中引入的功能性脑成像确实提供了一种体内研究脑-肠相互作用的方法，深入了解了内脏感觉的神经生物学机制，尤其是心理因素的影响，这种方法已经迅速发展。长大的。在本文中，将概述有关胃肠道感觉的大脑影像学证据，并特别强调影响情感和认知过程与内脏感觉之间相互作用的大脑机制。首先，将简要概述大脑与肠道（脑肠轴）之间的相互神经通路，包括健康志愿者的脑成像证据。其次，将更详细地讨论功能性脑成像研究，该研究评估心理因素对健康人的内脏感觉大脑处理的影响。最后，将重点研究研究健康志愿者与功能性胃肠疾病患者之间大脑对内脏扩张反应的差异的脑成像工作。

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