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首页> 外文期刊>World Journal of Gastroenterology >Effect of ethanol on pro-apoptotic mechanisms in polarized hepatic cells
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Effect of ethanol on pro-apoptotic mechanisms in polarized hepatic cells

机译：乙醇对极化肝细胞凋亡机制的影响

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摘要

Chronic ethanol consumption is associated with serious and potentially fatal alcohol-related liver injuries such as hepatomegaly, alcoholic hepatitis and cirrhosis. Moreover, it has been documented that the clinical progression of alcohol-induced liver damage may be associated with an increase in hepatocellular death that involves apoptotic mechanisms. Although much information has been learned about the clinical manifestations associated with alcohol-related diseases, the search continues for a better understanding of the molecular and/or cellular mechanisms by which ethanol exerts its deleterious effects such as the induction of pro-apoptotic mechanisms and related cell damaging events. As part of the effort to enhance our understanding of those particular cellular pathways and mechanisms associated with ethanol toxicity, researchers over the years have utilized a variety of model systems. Recently, work has come forth demonstrating the utility of a hybrid cell line (WIF-B) as a cell culture model system for the study of alcohol-associated alterations in hepatocellular mechanisms. Success with such emerging model systems could aid in the development of potential therapeutic treatments for the prevention of alcohol-induced apoptotic cell death that may ultimately serve as a significant target in delaying the onset and/or progression of clinical symptoms of alcohol-mediated liver disease. This review article summarizes the current understanding of ethanol-mediated modifications in cell survival and thus the promotion of pro-apoptotic events with emphasis on analyses made in various experimental model systems, particularly the more recently characterized WIF-B cell system.
机译：长期服用乙醇与严重和潜在致命的酒精相关性肝损伤有关，例如肝肿大，酒精性肝炎和肝硬化。而且，已经有文献证明，酒精引起的肝损伤的临床进展可能与涉及凋亡机制的肝细胞死亡的增加有关。尽管已了解到许多与酒精相关疾病相关的临床表现的信息，但人们仍在继续寻求对乙醇发挥其有害作用的分子和/或细胞机制的更好理解，如诱导促凋亡机制及其相关。细胞破坏事件。作为加深我们对与乙醇毒性相关的那些特定细胞途径和机制的理解的努力的一部分，多年来的研究人员已经利用了多种模型系统。近来，已经出现了工作，证明了杂种细胞系（WIF-B）作为细胞培养模型系统的用途，用于研究与酒精相关的肝细胞机制改变。此类新兴模型系统的成功可能有助于开发预防酒精诱导的凋亡细胞死亡的潜在治疗方法，该方法最终可能成为延缓酒精介导的肝病临床症状的发作和/或发展的重要目标。这篇综述文章总结了目前对乙醇介导的细胞存活修饰的理解，并因此促进了促凋亡事件的发展，重点是在各种实验模型系统，特别是最近表征的WIF-B细胞系统中进行的分析。

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