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首页> 外文期刊>World Journal of Gastroenterology >Clinical significance of subcellular localization of KL-6 mucin in primary colorectal adenocarcinoma and metastatic tissues.
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Clinical significance of subcellular localization of KL-6 mucin in primary colorectal adenocarcinoma and metastatic tissues.

机译：KL-6粘蛋白在原发性大肠腺癌和转移组织中亚细胞定位的临床意义。

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AIM: To assess subcellular localization of KL-6 mucin and its clinicopathological significance in colorectal carcinoma as well as metastatic lymph node and liver tissues. METHODS: Colorectal carcinoma tissues as well as metastatic lymph node and liver tissues were collected from 82 patients who underwent colorectomy or hepatectomy. Tissues were subjected to immunohistochemical analysis using KL-6 antibody. RESULTS: Of the 82 colorectal carcinoma patients, 6 showed no staining, 29 showed positive staining only in the apical membrane, and 47 showed positive staining in the circumferential membrane and/or cytoplasm. Positive staining was not observed in non-cancerous colorectal epithelial cells surrounding the tumor tissues. The five-year survival rate was significantly lower in cases showing positive staining in the circumferential membrane and/or cytoplasm (63.0%) than those showing positive staining only in the apical membrane (85.7%) and those showing no staining (100%). Statistical analysis between clinicopathological factors and subcellular localization of KL-6 mucin showed that KL-6 localization in the circumferential membrane and/or cytoplasm was significantly associated with the presence of venous invasion (P = 0.0003), lymphatic invasion (P<0.0001), lymph node metastasis (P<0.0001), liver metastasis (P = 0.058), and advanced histological stage (P<0.0001). Positive staining was observed in all metastatic lesions tested as well as in the primary colorectal carcinoma tissues. CONCLUSION: The subcellular staining pattern of KL-6 in colorectal adenocarcinoma may be an important indicator for unfavorable behaviors such as lymph node and liver metastasis, as well as for the prognosis of patients.
机译：目的：评估KL-6粘蛋白的亚细胞定位及其在大肠癌以及转移性淋巴结和肝组织中的临床病理意义。方法：收集82例行大肠切除术或肝切除术的患者的大肠癌组织以及转移性淋巴结和肝组织。使用KL-6抗体对组织进行免疫组织化学分析。结果：在82例大肠癌患者中，无染色6例，仅在顶端膜中有阳性染色，在外周膜和/或细胞质中有47例染色阳性。在肿瘤组织周围的非癌性结肠直肠上皮细胞中未观察到阳性染色。在外周膜和/或细胞质中呈阳性染色的病例（63.0％）的五年生存率显着低于仅在顶端膜中呈阳性染色的病例（85.7％）和没有染色的那些（100％）。临床病理因素与KL-6粘蛋白亚细胞定位之间的统计分析表明，KL-6定位在外周膜和/或细胞质中与静脉浸润（P = 0.0003），淋巴管浸润（P <0.0001），淋巴结转移（P <0.0001），肝转移（P = 0.058）和组织学晚期（P <0.0001）。在所有测试的转移性病变以及原发性结肠直肠癌组织中均观察到阳性染色。结论：KL-6在大肠腺癌中的亚细胞染色模式可能是不良行为如淋巴结转移和肝转移以及患者预后的重要指标。

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