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首页> 外文期刊>World Journal of Gastroenterology >Particularly interesting new cysteine-histidine rich protein expression in colorectal adenocarcinomas.
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Particularly interesting new cysteine-histidine rich protein expression in colorectal adenocarcinomas.

机译：在大肠腺癌中特别有趣的新的富含半胱氨酸-组氨酸的蛋白质表达。

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AIM: To study the relationship between particularly interesting new cysteine-histidine rich protein (PINCH) expression and clinicopathological factors in Chinese colorectal cancer patients. METHODS: The expression of PINCH was examined by immumohistochemistry in 141 samples of primary colorectal adenocarcinoma and 92 normal samples of colorectal mucosa. Eighty of the cases had both primary tumour and normal mucosa from the same patients. RESULTS: PINCH was expressed in the stroma of normal mucosa and tumours. PINCH expression in tumour-associated stroma was increased compared to normal mucosa in both unmatched cases (n = 141, c2 = 85.79, df = 3, P < 0.0001) and matched cases (n = 80, c2 = 45.86, df = 3, P < 0.0001). Among 135 tumours with visible invasive margin, 86 (64%) showed stronger PINCH expression at the invasive margin than in the intratumoural stroma. The frequency of PINCH strong expression in mucinous and signet-ring cell carcinomas was higher (52%) compared to non-mucinous carcinomas (29%, c2 = 5.13, P = 0.02). We did not find that PINCH expression was related to patient's gender, age, tumour location, tumour size, gross status, histological type, differentiation, invasion depth, lymph node status and Dukes'stage (P > 0.05). CONCLUSION: The expression of PINCH was upregulated in colorectal cancers, and especially at the margin of tumours, and further was related to mucinous and signet-ring cell carcinomas. The results suggest that expression of PINCH may be involved in the tumourigenesis and aggressiveness of colorectal cancers.
机译：目的：研究中国结直肠癌患者中特别有趣的新的富含半胱氨酸-组氨酸的蛋白（PINCH）的表达与临床病理因素之间的关系。方法：采用免疫组织化学方法检测141例原发性大肠腺癌标本和92例正常大肠黏膜标本中PINCH的表达。 80例同时患有原发肿瘤和正常黏膜。结果：PINCH在正常粘膜和肿瘤的基质中表达。与正常粘膜相比，在不匹配病例（n = 141，c2 = 85.79，df = 3，P <0.0001）和匹配病例（n = 80，c2 = 45.86，df = 3， P <0.0001）。在135例具有可见浸润边缘的肿瘤中，有86例（64％）在浸润边缘的PINCH表达高于肿瘤内基质。与非粘液性癌（29％，c2 = 5.13，P = 0.02）相比，在粘液性和印戒细胞癌中，PINCH强表达的频率更高（52％）。我们没有发现PINCH的表达与患者的性别，年龄，肿瘤位置，肿瘤大小，总体状态，组织学类型，分化，浸润深度，淋巴结状态和Dukes分期有关（P> 0.05）。结论：PINCH的表达在大肠癌中，特别是在肿瘤边缘上调，并与黏液性和印戒细胞癌有关。结果表明，PINCH的表达可能与大肠癌的肿瘤发生和侵袭性有关。

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