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首页> 外文期刊>World Journal of Gastroenterology >Differential c-erbB-1 and c-erbB-2 mRNA expression in cancer of the pancreas compared with cancer of the papilla of Vater.
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Differential c-erbB-1 and c-erbB-2 mRNA expression in cancer of the pancreas compared with cancer of the papilla of Vater.

机译：与Vater乳头状癌相比，胰腺癌中c-erbB-1和c-erbB-2 mRNA的差异表达。

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AIM: We examined quantitative mRNA expression of growth factor receptors (c-erbB-1, c-erbB-2) and the anti-apoptosis gene survivin known to be regulated in pancreatic adenocarcinomas and compared the expression pattern with that in carcinomas of the papilla of Vater. METHODS: Quantitative real-time reverse transcriptase-PCR (QRT-PCR, Taqman) was performed to analyze mRNA expression levels of c-erbB-1, c-erbB-2 and survivin in normal and corresponding tumor samples of 31 pancreatic adenocarcinomas and 8 cancers of the papilla of Vater. RESULTS: The overall median mRNA expression of survivin was significantly increased in both adenocarcinoma of the pancreas (P<0.01) and papilla of Vater (P<0.008) compared with uninvolved normal control tissue. In pancreatic cancer, expression of c-erbB-1 was significantly decreased compared with the normal pancreatic tissue (P<0.03), whereas in the cancer of the papilla of Vater expression of c-erbB-2 was significantly downregulated (P<0.05) compared with the paired normal samples. Gene expression was not associated with tumor stage, differentiation or prognosis. CONCLUSION: The common anti-apoptosis gene survivin is overexpressed both in the cancer of the papilla of Vater and pancreas. In contrast, the growth factor receptor genes c-erbB-1 and c-erbB-2 are differentially regulated in both tumor entities adding further evidence that pancreatic cancer is biologically different from the cancer of papilla of Vater.
机译：目的：我们研究了胰腺腺癌中生长因子受体（c-erbB-1，c-erbB-2）和抗凋亡基因survivin的定量mRNA表达，并将其与乳头状癌的表达模式进行了比较。 Vater。方法：采用实时定量逆转录PCR（Taqman，QRT-PCR）技术检测31例胰腺癌和8例正常胰腺癌及相应肿瘤样本中c-erbB-1，c-erbB-2和survivin的mRNA表达水平。瓦特乳头状癌。结果：与正常对照组相比，胰腺腺癌（P <0.01）和Vater乳头（P <0.008）中survivin的总体中值mRNA表达均显着增加。在胰腺癌中，与正常胰腺组织相比，c-erbB-1的表达显着降低（P <0.03），而在乳头状癌中，c-erbB-2的表达显着下调（P <0.05）。与配对的正常样本进行比较。基因表达与肿瘤分期，分化或预后无关。结论：常见的抗凋亡基因survivin在Vater乳头状癌和胰腺癌中均过表达。相反，生长因子受体基因c-erbB-1和c-erbB-2在两个肿瘤实体中均受差异调节，这进一步证明了胰腺癌在生物学上与Vater的乳头状癌有所不同。

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