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首页> 外文期刊>World Journal of Gastroenterology >Acute duodenal Crohn's disease successfully managed with low-speed elemental diet infusion via nasogastric tube: a case report.
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Acute duodenal Crohn's disease successfully managed with low-speed elemental diet infusion via nasogastric tube: a case report.

机译：通过鼻胃管低速元素饮食输注成功治疗了急性十二指肠克罗恩病：一例病例报告。

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摘要

Duodenal Crohn's disease is rare, and patients without obstruction are treated medically. We herein report one case whose duodenal Crohn's disease was successfully managed with low-speed elemental diet infusion through a nasogastric tube. A 28-year-old female developed acute duodenal Crohn's disease. Upper GI radiologic and endoscopic examinations showed a stricture in the duodenal bulb. Using the duodenal biopsy specimens, mucosal cytokine levels were measured; interleukin (IL)-1beta, IL-6, IL-8, and tumor necrosis factor-alpha levels were remarkably elevated. For initial 2 wk, powdered mesalazine was orally given but it was not effective. For the next 2 wk, she was treated with low-speed elemental diet therapy using a commercially available Elental(TM), which was infused continuously through a nasogastric tube using an infusion pump. The tip of the nasogastric tube was placed at an immediate oral side of the pylorus. The infusion speed was 10 mL/h (usual speed, 100 mL/h). After the 2-wk treatment, her symptoms were very much improved, and endoscopically, the duodenal stricture and inflammation improved. The duodenal mucosal cytokine levels remarkably decreased compared with those before the treatment. Although our experience was limited, low-speed elemental diet infusion through a nasogastric tube may be a useful treatment for acute duodenal Crohn's disease.
机译：十二指肠克罗恩病很罕见，没有梗阻的患者需要接受医学治疗。我们在此报告了一种通过鼻胃管低速元素饮食输注成功治疗十二指肠克罗恩病的病例。一名28岁的女性患了急性十二指肠克罗恩氏病。上消化道放射学和内窥镜检查显示十二指肠球狭窄。使用十二指肠活检标本，测量粘膜细胞因子水平。白介素（IL）-1beta，IL-6，IL-8和肿瘤坏死因子-α水平显着升高。在最初的2周内，口服美沙拉嗪粉末，但效果不佳。在接下来的两周中，使用市售的ElentalTM对她进行低速元素饮食治疗，并使用输液泵通过鼻胃管连续输液。将鼻胃管的尖端放置在幽门的直接口腔侧。输注速度为10 mL / h（通常速度为100 mL / h）。经过2周的治疗，她的症状得到了很大改善，并且在内窥镜下，十二指肠狭窄和炎症得到改善。与治疗前相比，十二指肠粘膜细胞因子水平明显降低。尽管我们的经验有限，但通过鼻胃管低速元素饮食输注可能是治疗急性十二指肠克罗恩氏病的有用方法。

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