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首页> 外文期刊>World Journal of Gastroenterology >Significance of Survivin and PTEN expression in full lymph node-examined gastric cancer.
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Significance of Survivin and PTEN expression in full lymph node-examined gastric cancer.

机译：Survivin和PTEN表达在全淋巴结检查的胃癌中的意义。

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AIM: To study the relationship between Survivin and PTEN expression and lymph node metastasis, depth of invasion and prognosis of gastric cancer patients in China. METHODS: Specimens of gastric cancer tissue were collected from the Affiliated Hospital of Jianghan University. All the 140 patients had complete examination data. All lymph nodes were found by the fat-clearing method. The interrupted serial 4-micron sections, routine hematoxylin and eosin staining and immunohistochemical methods were used to detect the lymph node metastases. Gastric cancer tissue microarray was performed to test the expression of Survivin and PTEN (17A) in gastric cancer by immunohistochemical method. All data were processed using chi2 test, Fisher's exact test, Kaplan-Meyer Log-rank method and Cox multivariate analysis (SPSS 12.0 software). RESULTS: One hundred and eighteen specimens were used in our tissue microarray (utilization rate was 82.4%). A total of 7580 lymph nodes were found. Metastases were found in 90 specimens and 1618 lymph nodes were detected. The positive rate of Survivin and PTEN expression was 52.5% (62/118) and 76.2% (90/118), respectively. A highly positive correlation was found between Survivin and PTEN expression (chi2 = 4.17, P = 0.04). Survivin expression was positively correlated with UICC N stage (chi 2 = 8.69, P = 0.03) and histological classification (chi2 = 4.41, P = 0.04) by chi2 tests. PTEN expression was positively correlated with depth of invasion (P = 0.02) and histological classification (chi2 = 5.47, P = 0.02). But Survivin and PTEN expressions were not related with prognosis of gastric cancer patients. A significant correlation between lymph node metastasis and prognosis was demonstrated by Cox multivariate analysis (chi2 = 4.85, P = 0.028). CONCLUSION: Survivin is positively correlated with PTEN expression in gastric cancer and is a molecular marker of lymph node metastasis while PTEN expression is a molecular marker of advanced gastric cancer. UICC N stage is the most important prognostic factor of gastric cancer in China.
机译：目的：探讨Survivin和PTEN表达与中国胃癌患者淋巴结转移，浸润深度及预后的关系。方法：从江汉大学附属医院收集胃癌组织标本。 140例患者均具有完整的检查数据。通过脂肪清除法发现所有淋巴结。中断的连续4微米切片，常规苏木精和曙红染色以及免疫组织化学方法用于检测淋巴结转移。用免疫组织化学方法检测胃癌组织微阵列，检测Survivin和PTEN（17A）在胃癌中的表达。所有数据均使用chi2检验，Fisher精确检验，Kaplan-Meyer Log-rank方法和Cox多变量分析（SPSS 12.0软件）进行处理。结果：在我们的组织芯片中使用了118个标本（利用率为82.4％）。共发现7580个淋巴结。在90个标本中发现了转移，检测到1618个淋巴结。 Survivin和PTEN表达的阳性率分别为52.5％（62/118）和76.2％（90/118）。在Survivin和PTEN表达之间发现高度正相关（chi2 = 4.17，P = 0.04）。通过chi2测试，survivin表达与UICC N分期（chi 2 = 8.69，P = 0.03）和组织学分类（chi2 = 4.41，P = 0.04）呈正相关。 PTEN表达与浸润深度（P = 0.02）和组织学分类（chi2 = 5.47，P = 0.02）呈正相关。但Survivin和PTEN的表达与胃癌患者的预后无关。 Cox多变量分析表明淋巴结转移与预后之间存在显着相关性（chi2 = 4.85，P = 0.028）。结论：Survivin与胃癌中PTEN的表达呈正相关，是淋巴结转移的分子标志物，而PTEN的表达则是晚期胃癌的分子标志物。 UICC N期是中国胃癌最重要的预后因素。

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