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首页> 外文期刊>World Journal of Gastroenterology >Expression of pituitary adenylate cyclase-activating polypeptide 1 and 2 receptor mRNA in gallbladder tissue of patients with gallstone or gallbladder polyps.
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Expression of pituitary adenylate cyclase-activating polypeptide 1 and 2 receptor mRNA in gallbladder tissue of patients with gallstone or gallbladder polyps.

机译：垂体腺苷酸环化酶激活多肽1和2受体mRNA在胆结石或胆囊息肉患者的胆囊组织中的表达。

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摘要

AIM: To detect the expression of pituitary adenylate cyclase-activating polypeptide receptor 1 (VPCAP1-R)and VPCAP2-R mRNA in gallbladder tissues of patients with gallstone or gallbladder polyps. METHODS: The expression of VPCAP1-R and VPCAP2-R mRNA in gallbladder tissues was detected in 25 patients with gallstone,8 patients with gallbladder polyps and 7 donors of liver transplantation by reverse transcription polymerase chain reaction (RT-PCR). RESULTS: The VPCAP2-R mRNA expression level in the control group (1.09+/-0.58) was lower than that in the gallbladder polyp group (1.64+/-0.56) and the gallstone group (1.55+/-0.45) (P<0.05) while the VPCAP1-R mRNA expression level in the control group (1.15+/-0.23) was not apparently different from that in the gallbladder polyp group (1.28+/-0.56) and the gallstone group (1.27+/-0.38). CONCLUSION: The abnormal expression of VPCAP2-R mRNA in gallbladder tissue may play a role in the formation of gallbladder stone and gallbladder polyps.
机译：目的：探讨垂体腺苷酸环化酶激活多肽受体1（VPCAP1-R）和VPCAP2-R mRNA在胆结石或胆囊息肉患者胆囊组织中的表达。方法：采用逆转录聚合酶链反应（RT-PCR）技术检测25例胆结石患者，8例胆囊息肉患者和7例肝移植供者胆囊组织中VPCAP1-R和VPCAP2-R mRNA的表达。结果：对照组的VPCAP2-R mRNA表达水平（1.09 +/- 0.58）低于胆囊息肉组（1.64 +/- 0.56）和胆结石组（1.55 +/- 0.45）（P < 0.05），而对照组（1.15 +/- 0.23）的VPCAP1-R mRNA表达水平与胆囊息肉组（1.28 +/- 0.56）和胆结石组（1.27 +/- 0.38）的表达水平无明显差异。结论：VPCAP2-R mRNA在胆囊组织中的异常表达可能与胆囊结石和胆囊息肉的形成有关。

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