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首页> 外文期刊>World Journal of Gastroenterology >Morphological observation of tumor infiltrating immunocytes in human rectal cancer.
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Morphological observation of tumor infiltrating immunocytes in human rectal cancer.

机译：人直肠癌中肿瘤浸润免疫细胞的形态学观察。

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AIM: To investigate the morphological characterization of tumor infiltrating dendritic cells (TIDCs) and tumor infiltrating lymphocytes (TILs) in human rectal cancer. METHODS: Light and electron microscopy as well as immunohistochemistry were used to observe the distributive and morphological changes of TIDCs and TILs. RESULTS: TIDCs were mainly located in tumor-surrounding tissue. The number of TIDCs in the earlier stage was higher than that in the later stage (P<0.01). TILs were mainly seen in adjacent tissue of cancers and tumor-surrounding tissue. There were more TILs in the earlier stage than that in the later stage (P<0.01). Under electron microscope, TIDCs were irregular in shape and exhibited many dendritic protrusions. It is not obvious that cancer cells perforated the basement membrane and TILs were arranged along the basement membrane in the earlier stage. In the later stage, it is explicit that cancer cells perforated the basement membrane and surrounded by TILs. There were contacts among TIDCs, TILs and tumor cell. One TIDCs contacted one or several TILs which clustered around TIDCs. Glycogen granules were seen between TIDCs and TILs. CONCLUSION: The number of TIDCs and TILs is related with tumor progression There exist close relationships among TIDCs, TILs and tumor cell.
机译：目的：探讨人直肠癌中肿瘤浸润性树突状细胞（TIDCs）和肿瘤浸润性淋巴细胞（TILs）的形态特征。方法：采用光镜和电镜观察免疫组织化学，观察TIDCs和TILs的分布和形态变化。结果：TIDCs主要位于肿瘤周围组织中。早期的TIDC数量高于后期的（P <0.01）。 TILs主要见于癌的邻近组织和肿瘤周围组织。与早期相比，早期的TILs更多（P <0.01）。在电子显微镜下，TIDC的形状是不规则的，并表现出许多树枝状突起。癌细胞穿透基膜并在较早阶段沿基膜排列TIL并不明显。在后期阶段，很明显癌细胞穿透了基底膜并被TIL包围。 TIDC，TIL和肿瘤细胞之间存在接触。一个TIDC联系了一个或多个TIL，这些TIL聚集在TIDC周围。在TIDC和TIL之间发现了糖原颗粒。结论：TIDCs和TILs的数量与肿瘤的进展有关。TIDCs，TILs与肿瘤细胞之间存在密切的关系。

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