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首页> 外文期刊>World Journal of Gastroenterology >Multimodal pain stimulation of the gastrointestinal tract.
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Multimodal pain stimulation of the gastrointestinal tract.

机译：胃肠道多模式疼痛刺激。

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摘要

Understanding and characterization of pain and other sensory symptoms are among the most important issues in the diagnosis and assessment of patient with gastrointestinal disorders. Methods to evoke and assess experimental pain have recently developed into a new area with the possibility for multimodal stimulation (e.g., electrical, mechanical, thermal and chemical stimulation) of different nerves and pain pathways in the human gut. Such methods mimic to a high degree the pain experienced in the clinic. Multimodal pain methods have increased our basic understanding of different peripheral receptors in the gut in health and disease. Together with advanced muscle analysis, the methods have increased our understanding of receptors sensitive to mechanical, chemical and temperature stimuli in diseases, such as systemic sclerosis and diabetes. The methods can also be used to unravel central pain mechanisms, such as those involved in allodynia, hyperalgesia and referred pain. Abnormalities in central pain mechanisms are often seen in patients with chronic gut pain and hence methods relying on multimodal pain stimulation may help to understand the symptoms in these patients. Sex differences have been observed in several diseases of the gut, and differences in central pain processing between males and females have been hypothesized using multimodal pain stimulations. Finally, multimodal methods have recently been used to gain more insight into the effect of drugs against pain in the GI tract. Hence, the multimodal methods undoubtedly represents a major step forward in the future characterization and treatment of patients with various diseases of the gut.
机译：在胃肠道疾病患者的诊断和评估中，疼痛和其他感觉症状的理解和表征是最重要的问题。引起和评估实验性疼痛的方法近来已发展到一个新的领域，它有可能对人体肠道中的不同神经和疼痛途径进行多峰刺激（例如，电，机械，热和化学刺激）。这样的方法在很大程度上模拟了临床中所经历的痛苦。多式联运的疼痛方法增加了我们对健康和疾病中肠中不同外周受体的基本了解。结合先进的肌肉分析，这些方法增加了我们对对系统性硬化症和糖尿病等疾病中的机械，化学和温度刺激敏感的受体的理解。这些方法也可用于阐明中枢性疼痛机制，例如涉及异常性疼痛，痛觉过敏和参考疼痛的机制。在患有慢性肠痛的患者中经常会出现中枢性疼痛机制异常，因此依赖多模式疼痛刺激的方法可能有助于了解这些患者的症状。已经在几种肠道疾病中观察到性别差异，并使用多峰疼痛刺激假设了男性和女性在中枢疼痛处理方面的差异。最后，最近已使用多峰方法对胃肠道疼痛药物的效果进行了更深入的了解。因此，多模式方法无疑代表了未来表征和治疗各种肠道疾病患者的重大进步。

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  • 来源
    《World Journal of Gastroenterology》 |2006年第16期|P.2477-2486|共10页
  • 作者

    Drewes AM; Gregersen H;

  • 作者单位

    Center for Visceral Biomechanics and Pain, Department of Medical Gastroenterology, Aalborg University Hospital, Denmark. drewes@smi.auc.dk;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 消化系及腹部疾病;
  • 关键词

    Gastrointestinal Tract; Pain; 疼痛;

    机译：Gastrointestinal Tract;Pain;疼痛;

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