Loss of interstitial cells of Cajal network in severe idiopathic gastroparesis.

Battaglia E; Bassotti G; Bellone G; Dughera L; Serra AM; Chiusa L; Repici A; Mioli P; Emanuelli G

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Loss of interstitial cells of Cajal network in severe idiopathic gastroparesis.

机译：严重特发性胃轻瘫中Cajal网络间质细胞的丢失。

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AIM: To report a case of severe idiopathic gastroparesis in complete absence of Kit-positive gastric interstitial cells of Cajal (ICC). METHODS: Gastric tissue from a patient with severe idiopathic gastroparesis unresponsive to medical treatment and requiring surgery was analyzed by conventional histology and immunohistochemistry. RESULTS: Gastric pacemaker cells expressing Kit receptor had completely disappeared while the local level of stem cell factor, the essential ligand for its development and maintenance, was increased. No signs of cell death were observed in the pacemaker region. CONCLUSION: These results are consistent with the hypothesis that a lack of Kit expression may lead to impaired functioning of ICC. Total gastrectomy proves to be curative.

机译：目的：报告一例完全没有Cajal的Kit阳性胃间质细胞（ICC）的严重特发性胃轻瘫的病例。方法：通过常规组织学和免疫组织化学分析严重特发性胃轻瘫患者的胃组织，该患者对药物无反应且需要手术治疗。结果：表达Kit受体的胃起搏器细胞完全消失，而干细胞因子（其发育和维持的必需配体）的局部水平升高。在起搏器区域未观察到细胞死亡的迹象。结论：这些结果与以下假设一致：缺乏Kit表达可能会导致ICC功能受损。全胃切除术被证明可以治愈。

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来源
《World Journal of Gastroenterology》 |2006年第38期|P.6172-6177|共6页
作者
Battaglia E; Bassotti G; Bellone G; Dughera L; Serra AM; Chiusa L; Repici A; Mioli P; Emanuelli G;
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作者单位

Department of Gastroenterology and Clinical Nutrition, University of Torino, Italy.;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类消化系及腹部疾病;
关键词
Gastroparesis; Gastric; Leydig Cells; network; 胃肌轻瘫; 莱迪希细胞;

机译：Gastroparesis;Gastric;Leydig Cells;network;胃肌轻瘫;莱迪希细胞;

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1. Physiology and pathophysiology of the interstitial cell of Cajal: from bench to bedside. I. Functional development and plasticity of interstitial cells of Cajal networks. [J] . Ward SM, Sanders KM American Journal of Physiology . 2001,第3期

机译：卡哈尔间质细胞的生理学和病理生理学：从长凳到床边。 I. Cajal网络间隙细胞的功能发展和可塑性。
2. Physiology and pathophysiology of the interstitial cells of Cajal: from bench to bedside. IV. Genetic and animal models of GI motility disorders caused by loss of interstitial cells of Cajal. [J] . Sanders KM, Ordog T, Ward SM American Journal of Physiology . 2002,第5期

机译：卡哈尔间质细胞的生理学和病理生理学：从长凳到床边。 IV。由Cajal间质细胞丢失引起的GI运动障碍的遗传和动物模型。
3. Evaluation of myenteric ganglion cells and interstitial cells of Cajal in patients with chronic idiopathic constipation. [J] . Yu CS, mc.seoul.kr, Kim HC, International journal of colorectal disease. . 2002,第4期

机译：慢性特发性便秘患者的肠神经节细胞和Cajal间质细胞的评估。
4. A Pipeline for the Registration of Calcium Transient Data to Structural Networks of the Interstitial Cells of Cajal [C] . Anna Qian, Shawn Means, John Malysz, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2019

机译：钙瞬态数据注册到Cajal间质细胞结构网络的管道
5. Intrinsic electrophysiological properties of interstitial cells of Cajal and smooth muscle cells. [D] . Lee, Jonathan Cheuk Fung. 1999

机译：Cajal间质细胞和平滑肌细胞的内在电生理特性。
6. Loss of interstitial cells of Cajal network in severe idiopathic gastroparesis [O] . Edda Battaglia, Gabrio Bassotti, Graziella Bellone, 2006

机译：严重特发性胃轻瘫中Cajal网络间质细胞的丢失
7. Loss of interstitial cells of Cajal network in severe idiopathic gastroparesis [O] . Edda Battaglia 2006

机译：严重特发性胃病中CAJAL网络间质细胞的丧失

Loss of interstitial cells of Cajal network in severe idiopathic gastroparesis.

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