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首页> 外文期刊>World Journal of Gastroenterology >Aggressive treatment of acute anal fissure with 0.5% nifedipine ointment prevents its evolution to chronicity.
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Aggressive treatment of acute anal fissure with 0.5% nifedipine ointment prevents its evolution to chronicity.

机译：0.5％硝苯地平软膏积极治疗急性肛裂可防止其发展为慢性病。

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摘要

AIM: To investigate the efficacy of topical application of 0.5% nifedipine ointment in healing acute anal fissue and preventing its progress to chronicity. METHODS: Thirty-one patients (10 males, 21 females) with acute anal fissure from September 1999 to January 2005 were treated topically with 0.5% nifedipine ointment (t.i.d.) for 8 wk. The patients were encouraged to follow a high-fiber diet and assessed at 2, 4 and 8 wk post-treatment. The healing of fissure and any side effects were recorded. The patients were subsequently followed up in the outpatient clinic for one year and contacted by phone every three months thereafter, while they were encouraged to come back if symptoms recurred. RESULTS: Twenty-seven of the 31 patients completed the 8-wk treatment course, of them 23 (85.2%) achieved a complete remission indicated by resolution of symptoms and healing of fissure. Of the remaining four unhealed patients (14.8%), 2 opted to undergo lateral sphincterotomy and the other 2 to continue therapy for four additional weeks, resulting in healing of fissure. All the 25 patients with complete remission had a mean follow-up of 22.9 +/- 14 (range 6-52) mo. Recurrence of symptoms occurred in four of these 25 patients (16%) who were successfully treated with an additional 4-wk course of 0.5% nifedipine ointment. Two of the 27 (7.4%) patients who completed the 8-wk treatment presented with moderate headache as a side effect of nifedipine. CONCLUSION: Topical 0.5% nifedipine ointment, used as an agent in chemical sphincterotomy, appears to offer a significant healing rate for acute anal fissure and might prevent its evolution to chronicity.
机译：目的：探讨局部应用0.5％硝苯地平软膏治疗急性肛门组织并预防其进展为慢性的疗效。方法：1999年9月至2005年1月对31例急性肛裂患者（男10例，女21例）进行局部治疗，用0.5％硝苯地平软膏（t.i.d.）治疗8周。鼓励患者遵循高纤维饮食，并在治疗后第2、4和8周进行评估。记录裂缝的愈合和任何副作用。随后对患者进行门诊随访一年，此后每三个月通过电话联系一次，如果症状再次出现，应鼓励他们回来。结果：31例患者中有27例完成了8周治疗过程，其中23例（85.2％）通过症状缓解和裂痕愈合表明完全缓解。其余四名未治愈的患者（14.8％）中，有2名选择进行了括约肌切开术，另2名选择了继续接受治疗另外四个星期，从而治愈了裂痕。 25例完全缓解的患者平均随访22.9 +/- 14个月（范围6-52）。在这25例患者中有4例（16％）出现了症状复发，这些患者成功接受了0.5％硝苯地平软膏的4周疗程。在完成8周治疗的27位患者中，有2位（7.4％）出现了中度头痛，这是硝苯地平的副作用。结论：局部用0.5％硝苯地平软膏作为化学括约肌切开术的制剂，似乎可以为急性肛裂提供显着的治愈率，并可能阻止其发展为慢性。

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