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首页> 外文期刊>World Journal of Gastroenterology >Randomized clinical trial on seven-day-per-week continuous accelerated irradiation for patients with esophageal carcinoma: Preliminary report on tumor response and acute toxicity
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Randomized clinical trial on seven-day-per-week continuous accelerated irradiation for patients with esophageal carcinoma: Preliminary report on tumor response and acute toxicity

机译：食管癌患者每周7天连续加速照射的随机临床试验：肿瘤反应和急性毒性的初步报告

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AIM: Tumor response and normal tissue toxicity of seven-day-per-week continuous accelerated irradiation (CAIR) for patients with esophageal carcinoma were evaluated and compared to conventional irradiation (CR). METHODS: Sixty patients with squamous cell carcinoma of the esophagus were randomized into two groups: the CAIR group (30 patients) and the CR group (30 patients). Patients in the CAIR group received radiotherapy (RT) with 2 Gy/fraction per day at 7 d/wk with a total dose of 50-70 Gy (average dose 64.2 Gy). The overall time of irradiation was 3.6-5.0 wk (average 4.6 wk). RT in the CR group was 2 Gy/fraction per day at 5 d/wk with a total dose of 40-70 Gy (average dose 61.7 Gy). The overall time of irradiation was 4.0-7.0 wk (average 6.4 wk). RESULTS: The data showed that the immediate tumor response to RT was better in the CAIR group than in the CR group. Efficiency rates (CR plus PR) were 82.8% (24/29) and 58.6% (17/29), respectively (P = 0.047). In both groups the incidences of esophagitis and tracheitis were insignificant (P = 0.376, 0.959), and no patient received toxicity that could not be tolerated. CONCLUSION: CAIR shortens overall treatment time and is well tolerated by patients. It may be superior to CR in enhancing the local response of tumor, but its remote effect for esophageal carcinoma awaits further follow-up.
机译：目的：评估食管癌患者每周7天连续加速照射（CAIR）的肿瘤反应和正常组织毒性，并将其与常规照射（CR）进行比较。方法：将60例食管鳞状细胞癌患者随机分为两组：CAIR组（30例）和CR组（30例）。 CAIR组的患者接受放射治疗（RT），每天7 d / wk，每天2 Gy /次，总剂量为50-70 Gy（平均剂量64.2 Gy）。辐照的总时间为3.6-5.0 wk（平均4.6 wk）。 CR组的RT在每天5 d / wk时为每天2 Gy /馏分，总剂量为40-70 Gy（平均剂量为61.7 Gy）。辐照的总时间为4.0-7.0 wk（平均6.4 wk）。结果：数据显示，CAIR组的肿瘤对RT的即时反应优于CR组。效率（CR加PR）分别为82.8％（24/29）和58.6％（17/29）（P = 0.047）。两组中食管炎和气管炎的发生率均不显着（P = 0.376，0.959），并且没有患者接受无法耐受的毒性反应。结论：CAIR缩短了整体治疗时间，患者对它的耐受性良好。它在增强肿瘤的局部反应方面可能优于CR，但其对食管癌的远距离作用尚待进一步随访。

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