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首页> 外文期刊>World Journal of Gastroenterology >Antimicrobial activity of Sapindus mukorossi and Rheum emodi extracts against H pylori: In vitro and in vivo studies.
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Antimicrobial activity of Sapindus mukorossi and Rheum emodi extracts against H pylori: In vitro and in vivo studies.

机译：Sapindus mukorossi和大黄大黄提取物对幽门螺杆菌的抗菌活性：体外和体内研究。

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AIM: to evaluate the antibacterial activity of Sapindus mukorossi (S. mukorossi) and Rheum emodi (R. emodi). METHODS: Powders of S. mukorossi and R. emodi were extracted successively with petroleum ether, benzene, chloroform and ethanol and were concentrated in vacuum. The disk diffusion method was used for in vitro studies and in vivo studies were performed on male Wister rats. Thirty resistant clinical isolates of H pylori, as determined by their antibiotic sensitivity patterns by E-test, along with two Gram +ve (S. aureus, B. subtilis) and two Gram -ve (E. coli, P. vugaris) organisms were screened for their susceptibility patterns against these extracts. RESULTS: In our screening, all 30 resistant isolates and the other four organisms (two Gram +ve S. aureus, B. subtilis and two Gram -ve, E. coli, P. vugaris) were sensitive to the test compounds. It was found that ethanol and chloroform extracts of S. mukorossi and ethanol and benzene extracts of R. emodi inhibited H pylori at very low concentrations. In the in vitro study, the isolates showed a considerable zone of inhibition at very low concentrations (10 mug/mL) for both the extracts. In the in vivo study, the H pylori infection was cleared with minimal doses of extracts of S. mukorossi (2.5 mg/mL) and R. emodi (3.0 mg/mL) given orally for seven days. CONCLUSION: We can conclude from this study that the extracts of S. mukorossi and R. emodi inhibited the growth of pylori in vitro and, in in vivo studies, the H pylori infection cleared within seven days at very low concentrations. We also found that H pylori did not acquire resistance against these herbal extracts even after 10 consecutive passages.
机译：目的：评估无患子（Sapindus mukorossi）（S。mukorossi）和大黄（Rheum emodi）（R。emodi）的抗菌活性。方法：先后用石油醚，苯，氯仿和乙醇提取麝香链球菌和红景天粉末，然后真空浓缩。圆盘扩散法用于体外研究，对雄性Wister大鼠进行体内研究。通过E检验通过抗生素敏感性模式确定的30株幽门螺杆菌临床分离株，以及两种革兰氏+ ve（金黄色葡萄球菌，枯草芽孢杆菌）和两种革兰氏ve（大肠杆菌，野性大肠杆菌）细菌。筛选了它们对这些提取物的敏感性模式。结果：在我们的筛选中，所有30种抗药性菌株和其他4种生物（两种革兰氏+金黄色葡萄球菌，枯草芽孢杆菌和两种革兰氏-VE，大肠杆菌，v。vugaris）对测试化合物敏感。发现S. mukorossi的乙醇和氯仿提取物以及R. emodi的乙醇和苯提取物在极低浓度下抑制幽门螺杆菌。在体外研究中，两种提取物在极低浓度（10杯/毫升）下均显示出明显的抑制区。在体内研究中，幽门螺杆菌感染可以通过口服7天的最小剂量的S. mukorossi（2.5 mg / mL）和R. emodi（3.0 mg / mL）提取物清除。结论：我们可以从这项研究中得出结论，S。mukorossi和R. emodi提取物在体外抑制幽门螺杆菌的生长，并且在体内研究中，幽门螺杆菌感染在很低的浓度下可在7天内清除。我们还发现，即使连续10次传代后，幽门螺杆菌也没有获得针对这些草药提取物的抗性。

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