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首页> 外文期刊>World Journal of Gastroenterology >Expression patterns and action analysis of genes associated with hepatitis virus infection during rat liver regeneration.
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Expression patterns and action analysis of genes associated with hepatitis virus infection during rat liver regeneration.

机译：大鼠肝再生过程中与肝炎病毒感染相关的基因的表达模式和作用分析。

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AIM: To study the action of hepatitis virus infection-associated genes at transcription level during liver regeneration (LR). METHODS: Hepatitis virus infection-associated genes were obtained by collecting the data from databases and retrieving the correlated articles, and their expression changes in the regenerating rat liver were detected with the rat genome 230 2.0 array. RESULTS: Eighty-eight genes were found to be associated with liver regeneration. The number of genes initially and totally expressed during initial LR [0.5-4 h after partial hepatectomy (PH)], transition from G0 to G1 (4-6 h after PH), cell proliferation (6-66 h after PH), cell differentiation and reorganization of structure-function (66-168 h after PH) was 37, 8, 48, 3 and 37, 26, 80, 57, respectively, indicating that the genes were mainly triggered at the early stage of LR (0.5-4 h after PH), and worked at different phases. These genes were classified into 5 types according to their expression similarity, namely 37 up-regulated, 9 predominantly up-regulated, 34 down-regulated, 6 predominantly down-regulated and 2 up/down-regulated genes. Their total up- and down-regulation frequencies were 359 and 149 during LR, indicating that the expression of most genes was enhanced, while the expression of a small number of genes was attenuated during LR. According to time relevance, they were classified into 12 groups (0.5 and 1 h, 2 and 4 h, 6 h, 8 and 12 h, 16 and 96 h, 18 and 24 h, 30 and 42 h, 36 and 48 h, 54 and 60 h, 66 and 72 h, 120 and 144 h, 168 h), demonstrating that the cellular physiological and biochemical activities during LR were fluctuated. According to expression changes of the genes, their expression patterns were classified into 23 types, suggesting that the cellular physiological and biochemical activities during LR were diverse and complicated. CONCLUSION: The anti-virus infection capacity of regenerating liver can be enhanced and 88 genes play an important role in LR.
机译：目的：研究肝再生期间肝炎病毒感染相关基因在转录水平的作用。方法：通过收集数据库数据并检索相关文章，获得肝炎病毒感染相关基因，并用大鼠基因组230 2.0阵列检测其在再生大鼠肝脏中的表达变化。结果：发现88个基因与肝脏再生有关。初始LR [部分肝切除术后（PH）后0.5-4 h]，从G0过渡到G1（PH后4-6 h），细胞增殖（PH后6-66 h），细胞最初和全部表达的基因数量结构功能的分化和重组（PH后66-168 h）分别为37、8、48、3和37、26、80、57，表明这些基因主要在LR的早期（0.5- PH后4小时），并在不同阶段工作。根据它们的表达相似性将这些基因分为5种类型，即37种上调，9种主要上调，34种下调，6种主要下调和2种上/下调基因。它们在LR期间的总上调和下调频率分别为359和149，表明大多数基因的表达得到增强，而少数基因的表达在LR期间减弱。根据时间相关性，将其分为12组（0.5和1小时，2和4小时，6小时，8和12小时，16和96小时，18和24小时，30和42小时，36和48小时， 54和60小时，66和72小时，120和144小时，168小时）表明LR期间的细胞生理和生化活性发生了波动。根据基因的表达变化，将它们的表达模式分为23种，提示LR过程中细胞的生理生化活性是多样且复杂的。结论：可增强再生肝的抗病毒感染能力，其中88个基因在LR中起重要作用。

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