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首页> 外文期刊>World Journal of Gastroenterology >Persistent CXCR4 expression after preoperative chemoradiotherapy predicts early recurrence and poor prognosis in esophageal cancer.
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Persistent CXCR4 expression after preoperative chemoradiotherapy predicts early recurrence and poor prognosis in esophageal cancer.

机译：术前放化疗后持续的CXCR4表达可预示食管癌的早期复发和不良预后。

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AIM: To study the effect of CXC chemokine receptor-4 (CXCR4) expression on disease progression and prognosis in esophageal cancer. METHODS: CXCR4 expression was evaluated in 37 patients with histologically confirmed esophageal squamous carcinomas (ESCC) undergoing preoperative chemoradiotherapy (CRT) by immunohistochemical staining. RESULTS: Eleven out of 37 ESCC patients showed a pathological complete response (CR) after CRT. CXCR4 protein expression was observed in cell cytoplasms of 13 tumors, and null expression was seen in 13 tumors. Distant recurrence was significantly more common in patients with positive CXCR4 expression (P = 0.0318). After a median follow-up time of 31.6 mo, 19 patients progressed (12 of 19 expressed positive CXCR4) and 11 died (10 of 11 expressed positive CXCR4). Overall survival was significantly correlated with lymph node metastasis (952.1 +/- 53.8 d in negative group vs 475.1 +/- 56.2 d in positive group, P = 0.023), distant metastasis (874.0 +/- 60.4 d in negative group vs 434.9 +/- 75.2 d in positive group, P = 0.014) and CRT (811.5 +/- 51.2 d in responder group vs 459.6 +/- 94.0 d in non-responder group, P = 0.00038) and further with an absence of CXCR4 expression or no residual tumor (959.8 +/- 51.0 d in null expression or no tumor group vs 412.0 +/- 57.1 d in positive expression group, P = 0.0001). CONCLUSION: Persistent positive CXCR4 expression is implicated in tumor aggressiveness and poor prognosis in ESCC after CRT, and preoperative CRT may improve the prognosis of ESCC via CXCL12-CXCR4 signaling pathway.
机译：目的：研究CXC趋化因子受体4（CXCR4）表达对食管癌疾病进展和预后的影响。方法：采用免疫组织化学染色法，对37例经组织学证实的食管鳞癌（ESCC）行术前放化疗（CRT）的患者进行CXCR4表达评估。结果：37例ESCC患者中有11例在CRT后表现出病理完全缓解（CR）。在13个肿瘤的细胞质中观察到CXCR4蛋白表达，在13个肿瘤中观察到无效表达。 CXCR4表达阳性的患者远处复发更为普遍（P = 0.0318）。中位随访时间为31.6 mo之后，有19例患者进展（19例中有12例CXCR4阳性），11例死亡（11例中有10例CXCR4阳性）。总生存率与淋巴结转移（阴性组952.1 +/- 53.8 d，阳性组475.1 +/- 56.2 d，P = 0.023），远处转移（阴性组874.0 +/- 60.4 d vs 434.9 +）显着相关。阳性组为75.2 d，P = 0.014）和CRT（应答组为811.5 +/- 51.2 d，非应答组为459.6 +/- 94.0 d，P = 0.00038），并且进一步缺乏CXCR4表达或无残留肿瘤（无表达或无肿瘤组为959.8 +/- 51.0 d，阳性表达组为412.0 +/- 57.1 d，P = 0.0001）。结论：持续的CXCR4阳性表达与CRT后ESCC的肿瘤侵袭性和预后不良有关，术前CRT可通过CXCL12-CXCR4信号通路改善ESCC的预后。

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