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首页> 外文期刊>World Journal of Gastroenterology >Expression patterns and action analysis of genes associated with physiological responses during rat liver regeneration: Innate immune response.
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Expression patterns and action analysis of genes associated with physiological responses during rat liver regeneration: Innate immune response.

机译：大鼠肝脏再生过程中与生理反应相关的基因的表达模式和作用分析：先天免疫反应。

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AIM: To study the relationship between innate immune response and liver regeneration (LR) at transcriptional level. METHODS: Genes associated with innate immunity response were obtained by collecting the data from databases and retrieving articles. Gene expression changes in rat regenerating liver were detected by rat genome 230 2.0 array. RESULTS: A total of 85 genes were found to be associated with LR. The initially and totally expressed number of genes at the phases of initiation [0.5-4 h after partial hepatectomy (PH)], transition from G0 to G1 (4-6 h after PH), cell proliferation (6-66 h after PH), cell differentiation and structure-function reconstruction (66-168 h after PH) was 36, 9, 47, 4 and 36, 26, 78, 50, respectively, illustrating that the associated genes were mainly triggered at the initial phase of LR and worked at different phases. According to their expression similarity, these genes were classified into 5 types: 41 up-regulated, 4 predominantly up-regulated, 26 down-regulated, 6 predominantly down-regulated, and 8 approximately up/down-regulated genes, respectively. The expression of these genes was up-regulated 350 times and down-regulated 129 times respectively, demonstrating that the expression of most genes was enhanced while the expression of a small number of genes was decreased during LR. Their time relevance was classified into 14 groups, showing that the cellular physiological and biochemical activities during LR were staggered. According to the gene expression patterns, they were classified into 28 types, indicating that the cellular physiological and biochemical activities were diverse and complicated during LR. CONCLUSION: Congenital cellular immunity is enhanced mainly in the forepart, prophase and anaphase of LR while congenital molecular immunity is increased dominantly in the forepart and anaphase of LR. A total of 85 genes associated with LR play an important role in innate immunity.
机译：目的：从转录水平研究先天免疫反应与肝脏再生（LR）的关系。方法：通过收集数据库中的数据并检索文章，获得与先天免疫应答相关的基因。通过大鼠基因组230 2.0阵列检测了大鼠再生肝中的基因表达变化。结果：共发现与LR相关的85个基因。在开始阶段[部分肝切除术（PH）后0.5-4小时]，从G0过渡到G1（PH后4-6小时），细胞增殖（PH后6-66小时）的初始和全部表达的基因数量，细胞分化和结构功能重建（PH后66-168 h）分别为36、9、47、4和36、26、78、50，说明相关基因主要在LR和LR的初始阶段触发。在不同的阶段工作。根据它们的表达相似性，这些基因分为5种类型：分别是41个上调基因，4个主要上调基因，26个下调基因，6个主要下调基因和8个大约上调/下调基因。这些基因的表达分别被上调了350倍和下调了129倍，表明LR期间大多数基因的表达增强，而少数基因的表达降低。他们的时间相关性分为14组，表明LR期间的细胞生理和生化活性是交错的。根据基因表达方式，将它们分为28种类型，表明LR期间细胞的生理和生化活性是多样且复杂的。结论：先天性细胞免疫主要在LR的前，后期和后期增强，而先天性分子免疫则主要在LR的前，后期增强。与LR相关的总共85个基因在先天免疫中起重要作用。

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