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首页> 外文期刊>World Journal of Gastroenterology >Role of the HLA-DQ locus in the development of chronic gastritis and gastric carcinoma in Mexican patients.
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Role of the HLA-DQ locus in the development of chronic gastritis and gastric carcinoma in Mexican patients.

机译：HLA-DQ基因座在墨西哥患者慢性胃炎和胃癌发展中的作用。

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摘要

AIM: To determine the HLA-DQ locus in Mexican patients with Chronic gastritis and gastric adenocarcinoma. METHODS: Oligotyping for HLA-DQ locus was performed in 45 Mexican patients with chronic gastritis and 13 Mexican patients with diffuse-type gastric adenocarcinoma, and was then compared with 99 clinically healthy unrelated individuals. H pylori infection and CagA status were assessed in patients by enzyme-linked immunosorbent assay (ELISA) method. RESULTS: We found a significant increased frequency of HLA-DQB1*0401 allele in H pylori-positive patients with chronic gastritis when compared with healthy subjects [19 vs 0%, P = 1 multiply 10(-7), odds ratio (OR) = 4.96; 95% confidence interval (95% CI), 3.87-6.35]. We also found a significant increased frequency of HLA-DQB1*0501 in patients with diffuse-type gastric carcinoma in comparison with healthy individuals (P = 1 multiply 10(-6), OR = 13.07; 95% CI, 2.82-85.14). CONCLUSION: HLA-DQ locus may play a different role in the development of H pylori-related chronic gastritis and diffuse-type gastric adenocarcinoma in the Mexican Mestizo population.
机译：目的：确定墨西哥慢性胃炎和胃腺癌患者的HLA-DQ基因座。方法：对45例墨西哥慢性胃炎患者和13例墨西哥弥漫型胃腺癌患者进行了HLA-DQ基因位点基因分型，然后与99名临床健康无关个体进行比较。通过酶联免疫吸附测定（ELISA）方法评估患者的幽门螺杆菌感染和CagA状态。结果：我们发现与健康受试者相比，慢性胃炎的幽门螺杆菌阳性患者中HLA-DQB1 * 0401等位基因频率显着增加[19 vs 0％，P = 1乘以10（-7），优势比（OR） = 4.96； 95％置信区间（95％CI），3.87-6.35]。我们还发现，与健康个体相比，弥漫型胃癌患者的HLA-DQB1 * 0501频率显着增加（P = 1乘以10（-6），OR = 13.07； 95％CI，2.82-85.14）。结论：HLA-DQ基因座在墨西哥Mestizo人群中与幽门螺杆菌相关的慢性胃炎和弥漫型胃腺癌的发展中可能起不同的作用。

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