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首页> 外文期刊>World Journal of Gastroenterology >Value of portal hemodynamics and hypersplenism in cirrhosis staging.
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Value of portal hemodynamics and hypersplenism in cirrhosis staging.

机译：门静脉血流动力学和脾功能亢进在肝硬化分期中的价值。

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AIM: To determine the correlation between portal hemodynamics and spleen function among different grades of cirrhosis and verify its significance in cirrhosis staging. METHODS: The portal and splenic vein hemodynamics and spleen size were investigated by ultrasonography in consecutive 38 cirrhotic patients with cirrhosis (Child's grades A to C) and 20 normal controls. The differences were compared in portal vein diameter and flow velocity between patients with and without ascites and between patients with mild and severe esophageal varices. The correlation between peripheral blood cell counts and Child's grades was also determined. RESULTS: The portal flow velocity and volume were significantly lower in patients with Child's C (12.25+/-1.67 cm/s vs 788.59+/-234 mm/min, respectively) cirrhosis compared to controls (19.55+/-3.28 cm/s vs 1254.03+/-410 mm/min, respectively) and those with Child's A (18.5+/-3.02 cm/s vs 1358.48+/-384 mm/min, respectively) and Child's B (16.0+/-3.89 cm/s vs 1142.23+/-390 mm/min, respectively) cirrhosis. Patients with ascites had much lower portal flow velocity and volume (13.0+/-1.72 cm/s vs 1078+/-533 mm/min) than those without ascites (18.6+/-2.60 cm/s vs 1394+/-354 mm/min). There was no statistical difference between patients with mild and severe esophageal varices. The portal vein diameter was not significantly different among the above groups. There were significant differences in splenic vein diameter, flow velocity and white blood cell count, but not in spleen size, red blood cell and platelet counts among the various grades of cirrhosis. The spleen size was negatively correlated with red blood cell and platelet counts (r = -0.620 and r = -0.8.34, respectively). CONCLUSION: An optimal system that includes parameters representing the portal hemodynamics and spleen function should be proposed for cirrhosis staging.
机译：目的：确定不同级别肝硬化患者门脉血流动力学与脾功能之间的相关性，并验证其在肝硬化分期中的意义。方法：通过超声检查连续38例肝硬化肝硬化患者（儿童A至C级）和20例正常对照者的门静脉和脾静脉血流动力学和脾脏大小。比较有无腹水患者和轻度和重度食管静脉曲张患者之间门静脉直径和流速的差异。还确定了外周血细胞计数与Child's等级之间的相关性。结果：与对照组（19.55 +/- 3.28 cm / s）相比，Child's C肝硬化患者的门脉流速和容积显着降低（分别为12.25 +/- 1.67 cm / s和788.59 +/- 234 mm / min）。分别为1254.03 +/- 410 mm / min）和儿童A（分别为18.5 +/- 3.02 cm / s和1358.48 +/- 384 mm / min）和儿童B（16.0 +/- 3.89 cm / s）分别为1142.23 +/- 390 mm / min）。腹水患者的门静脉血流速度和容量（13.0 +/- 1.72 cm / s比1078 +/- 533 mm / min）要低得多，而无腹水的患者（18.6 +/- 2.60 cm / s对1394 +/- 354 mm / s） / min）。轻度和重度食管静脉曲张患者之间无统计学差异。上述各组门静脉直径无明显差异。在不同级别的肝硬化中，脾静脉直径，流速和白细胞计数存在显着差异，但脾脏大小，红细胞和血小板计数无显着差异。脾脏大小与红细胞和血小板计数呈负相关（分别为r = -0.620和r = -0.8.34）。结论：对于肝硬化分期，应提出一个包括代表门脉血流动力学和脾功能的参数的最佳系统。

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