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首页> 外文期刊>World Journal of Gastroenterology >Effect of Helicobacter pylori eradication on gastric hyperplastic polyposis in Cowden's disease.
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Effect of Helicobacter pylori eradication on gastric hyperplastic polyposis in Cowden's disease.

机译：根除幽门螺杆菌对考登病胃增生性息肉的影响。

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摘要

A 21-year-old woman with complaints of hematochezia was diagnosed as having Cowden's disease (CD), an autosomal dominant condition characterized by multiple hamartomas, since facial papules and gingival papillomas were identified. On endoscopy, multiple hyperplastic polyps were seen in the rectum and left-side colon. There were also esophageal glycogenic acanthosis and hyperplastic polyposis in the antrum accompanied by Helicobacter pylori-related gastritis. Although gastric hyperplastic polyposis had by no means regressed with unsuccessful first-line eradication therapy for H pylori, following cure of the infection with salvage therapy consisting of rabeprazole, amoxicillin and metronidazole, the polyposis lesions almost disappeared. Follow-up gastroscopy 2 and 3 years after cessation of the second-line eradication therapy revealed almost complete regression of the polyposis lesions with no evidence of H pylori infection. We recommend eradication treatment for CD patients with gastric hyperplastic polyps and the infection, as the occurrence of gastric carcinoma among hyperplastic polyps has been described.
机译：由于发现了面部丘疹和牙龈乳头状瘤，一名患有便血病的21岁妇女被诊断出患有Cowden病（CD），这是常染色体显性疾病，特征是多发错构瘤。内窥镜检查在直肠和左侧结肠可见多个增生性息肉。在胃中也有食管糖原性棘皮症和增生性息肉病，并伴有幽门螺杆菌相关性胃炎。尽管胃增生性息肉病并没有因幽门螺杆菌一线根除术的失败而退缩，但是在由雷贝拉唑，阿莫西林和甲硝唑组成的挽救疗法治愈感染后，息肉病几乎消失了。停止二线根除治疗后2年和3年的随访胃镜检查显示息肉病灶几乎完全消退，没有幽门螺杆菌感染的迹象。我们建议对患有胃增生性息肉和感染的CD患者进行根除治疗，因为已经描述了胃增生性息肉中胃癌的发生。

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