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首页> 外文期刊>Journal of gastroenterology and hepatology >Planning mass eradication of Helicobacter pylori Helicobacter pylori Helicobacter pylori infection for indigenous Taiwanese peoples to reduce gastric cancer
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Planning mass eradication of Helicobacter pylori Helicobacter pylori Helicobacter pylori infection for indigenous Taiwanese peoples to reduce gastric cancer

机译：规划群幽门螺杆菌幽门螺杆菌幽门螺杆菌幽门螺杆菌感染对土着台湾人民幽门螺杆菌感染减少胃癌

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Abstract Background and Aim The aim of this study is to identify gastric cancer burden in Indigenous Taiwanese peoples and conduct a project to evaluate how to reduce the disparities most effectively in Indigenous communities. Methods First, we quantified the health disparities in gastric cancer in Indigenous peoples using data from the cancer registries during the period of 2006–2014. Second, we identified parameters that might be associated with Helicobacter pylori infection or help identify a good eradication strategy. Results Gastric cancer incidence (24.4 vs 12.3 per 100?000 person‐years) and mortality rates (15.8 vs 6.8 per 100?000 person‐years) were higher in Indigenous than in non‐Indigenous, with 2.19‐fold (95% confidence interval [CI]: 2.06–2.33) and 2.47‐fold (2.28–2.67) increased risk, respectively. In Indigenous communities, H .? pylori infection was more prevalent in Indigenous than in non‐Indigenous (59.4% vs 31.5%, P ??0.01). Regression analyses consistently showed that either the mountain or plain Indigenous had 1.89‐fold (95% CI: 1.34–2.66) and 1.73‐fold (95% CI: 1.24–2.41) increased risk for H .? pylori infection, respectively, as compared with non‐Indigenous, adjusting for other baseline characteristics. The high infection rates were similarly seen in young, middle‐aged, and older adults. Program eradication rates using clarithromycin‐based triple therapy were suboptimal (73.7%, 95% CI: 70.0–77.4%); the habits of smoking (1.70‐fold, 95% CI: 1.01–2.39) and betel nut chewing (1.54‐fold, 95% CI: 0.93–2.16) were associated with the higher risk of treatment failure. Conclusion Gastric cancer burden is higher in Indigenous Taiwanese peoples than in their non‐Indigenous counterparts. Eliminating the prevalent risk factor of H .? pylori infection is a top priority to reduce this health disparity.
机译：摘要背景和目的本研究的目的是鉴定土着台湾人民的胃癌负担，并进行项目以评估如何在土着社区最有效地减少差异。方法首先，我们在2006 - 2014年期间使用来自癌症注册管理机构的数据量化土着人民中胃癌的健康差异。其次，我们鉴定了可能与幽门螺杆菌感染或帮助识别良好的根除策略相关的参数。结果胃癌发病率（每100 000人的12.3次）和死亡率（每100.8 vs 6.8 / 000人 - 年）比非土着较高，2.19倍（95％置信区间[CI]：2.06-2.33）和2.47倍（2.28-2.67）分别增加风险。在土着社区，h。？ Pylori感染在土着普遍存在于非本土（59.4％vs 31.5％，p≤0.01）。回归分析一致地显示山或普通土着土着土产有1.89倍（95％CI：1.34-2.66）和1.73倍（95％CI：1.24-2.41）的风险增加了。？幽门螺杆菌分别与非本土化相比，调整其他基线特征。在年轻，中年和老年人身上相似地看到了高感染率。使用基于Clarithromycin的三重疗法的计划根除率次优（73.7％，95％CI：70.0-77.4％）;吸烟习惯（1.70倍，95％CI：1.01-2.39）和槟榔咀嚼（1.54倍，95％CI：0.93-2.16）与治疗失败风险较高有关。结论土着台湾人民胃癌负担高于非土着对应物的胃癌负担。消除了普遍的危险因素h。？幽门螺杆菌感染是减少这种健康差异的首要任务。

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