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首页> 外文期刊>World Journal of Gastroenterology >A community-based epidemiological study of elevated serum alanine aminotransferase levels in Kinmen, Taiwan.
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A community-based epidemiological study of elevated serum alanine aminotransferase levels in Kinmen, Taiwan.

机译：台湾金门市基于社区的流行病学研究，血清丙氨酸转氨酶水平升高。

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摘要

AIM: To explore any gender-related differences in prevalence of and condition-associated factors related to an elevated serum alanine aminotransferase (ALT) level amongst residents of Kinmen, Taiwan. METHODS: A total of 11 898 of a potential 20 112 regional residents aged 30 years or more completed a related questionnaire that was carried out by the Yang-Ming Crusade between 1991 and 1994 inclusively, with blood samples being collected by public nurses. The overall questionnaire response rate was 59.3% (52.4% for males and 66.0% for females). RESULTS: The prevalence of an elevated serum ALT level for this sub-population was found to be 7.2%, the prevalence revealing a statistically significant decrease with increasing population age (P<0.0001). Males exhibited a greater prevalence of elevated serum ALT level than did females (9.4% vs 5.3%, P<0.0001). Using multiple logistic regression analysis, in addition to male gender, a younger age, greater waist circumference, presence of type-2 diabetes and hyperuricemia were the significant factors associated with an elevated serum ALT level for both males and females. Gender-related differences as regards associated factors were also revealed. For males, obesity was significantly related to an elevated serum ALT level (OR = 1.28, 95%CI: 1.00-1.66) but this was not so for females (OR = 1.09, 95%CI: 0.84-1.42). Hypertriglyceridemia (OR = 1.80, 95%CI: 1.36-2.39) and hyperuricemia (OR = 1.61, 95%CI: 1.03-2.52) were significantly related to elevated serum ALT levels only for females. CONCLUSION: Several gender-related differences were noted pertaining to the prevalence of and relationship between obesity, hypertriglyceridemia and hyperuricemia and elevated serum ALT level in the present study.
机译：目的：探讨台湾金门市居民血清丙氨酸氨基转移酶（ALT）水平升高与患病率及病情相关因素的性别相关差异。方法：在1991年至1994年期间，由杨明远征队（Yang-Ming Crusade）进行了包括年龄在30岁或30岁以上的潜在20112名地区居民中的11898名相关调查表，并由公共护士采集了血样。总体问卷答复率为59.3％（男性为52.4％，女性为66.0％）。结果：该亚群的血清ALT水平升高的患病率为7.2％，该患病率随人口年龄的增加而具有统计学上的显着降低（P <0.0001）。男性比女性表现出更高的血清ALT水平升高（9.4％比5.3％，P <0.0001）。使用多元逻辑回归分析，除男性性别外，更年轻，腰围更大，2型糖尿病的存在和高尿酸血症是与男性和女性血清ALT水平升高相关的重要因素。还揭示了在相关因素方面与性别有关的差异。对于男性，肥胖与血清ALT水平升高显着相关（OR = 1.28，95％CI：1.00-1.66），但对于女性而言并非如此（OR = 1.09，95％CI：0.84-1.42）。高甘油三酸酯血症（OR = 1.80，95％CI：1.36-2.39）和高尿酸血症（OR = 1.61，95％CI：1.03-2.52）仅与女性的血清ALT水平升高显着相关。结论：本研究发现肥胖，高甘油三酯血症和高尿酸血症的患病率及其相关性以及血清ALT水平升高与性别有关。

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