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首页> 外文期刊>World Journal of Gastroenterology >Head-to-head comparison of H_2-receptor antagonists and proton pump inhibitors in the treatment of erosive esophagitis: A meta-analysis
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Head-to-head comparison of H_2-receptor antagonists and proton pump inhibitors in the treatment of erosive esophagitis: A meta-analysis

机译：H_2受体拮抗剂和质子泵抑制剂治疗糜烂性食管炎的头对头比较：一项荟萃分析

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AIM: To systematically evaluate the efficacy of H_2-receptor antagonists (H_2RAs) and proton pump inhibitors in healing erosive esophagitis (EE). METHODS: A meta-analysis was performed. A literature search was conducted in PubMed, Medline, Embase, and Cochrane databases to include randomized controlled head-to-head comparative trials evaluating the efficacy of H_2RAs or proton pump inhibitors in healing EE. Relative risk (RR) and 95% confidence interval (CI) were calculated under a random-effects model. RESULTS: RRs of cumulative healing rates for each comparison at 8 wk were: high dose vs standard dose H_2RAs, 1.17 (95%CI, 1.02-1.33); standard dose proton pump inhibitors vs standard dose H_2RAs, 1.59 (95%CI, 1.44-1.75); standard dose other proton pump inhibitors vs standard dose omeprazole, 1.06 (95%CI, 0.98-1.06). Proton pump inhibitors produced consistently greater healing rates than H_2RAs of all doses across all grades of esophagitis, including patients refractory to H_2RAs. Healing rates achieved with standard dose omeprazole were similar to those with other proton pump inhibitors in all grades of esophagitis. CONCLUSION: H_2RAs are less effective for treating patients with erosive esophagitis, especially in those with severe forms of esophagitis. Standard dose proton pump inhibitors are significantly more effective than H_2RAs in healing esophagitis of all grades. Proton pump inhibitors given at the recommended dose are equally effective for healing esophagitis.
机译：目的：系统评价H_2受体拮抗剂（H_2RAs）和质子泵抑制剂在治疗糜烂性食管炎（EE）中的疗效。方法：进行荟萃分析。在PubMed，Medline，Embase和Cochrane数据库中进行了文献检索，以包括评估H_2RA或质子泵抑制剂在治疗EE中的功效的随机对照的头对头比较试验。在随机效应模型下计算相对风险（RR）和95％置信区间（CI）。结果：8周时每次比较的累积治愈率RR为：高剂量vs标准剂量H_2RAs为1.17（95％CI，1.02-1.33）；标准剂量质子泵抑制剂与标准剂量H_2RAs 1.59（95％CI，1.44-1.75）;标准剂量的其他质子泵抑制剂与标准剂量的奥美拉唑1.06（95％CI，0.98-1.06）。在所有级别的食管炎中，包括对H_2RA难治的患者，质子泵抑制剂产生的治愈率始终高于所有剂量的H_2RA。在所有级别的食管炎中，使用标准剂量的奥美拉唑实现的治愈率与使用其他质子泵抑制剂的治愈率相似。结论：H_2RAs治疗糜烂性食管炎的效果较差，特别是对于严重形式的食管炎。在所有级别的治愈性食管炎中，标准剂量的质子泵抑制剂比H_2RA明显更有效。推荐剂量的质子泵抑制剂对治愈食管炎同样有效。

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