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首页> 外文期刊>World Journal of Gastroenterology >Circulating adhesion molecules in patients with virus-related chronic diseases of the liver
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Circulating adhesion molecules in patients with virus-related chronic diseases of the liver

机译：肝病毒相关慢性疾病患者的循环黏附分子

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AIM: In the inflammatory state, intercellular adhesion molecule-1 (ICAM-1) and vascular cellular adhesion molecule-1 (VCAM-1) play a key role in promoting migration of immunological cells from the circulation to target site. Aim of our study was to investigate soluble forms of these molecules in patients with virus-related chronic liver diseases, to assess their behavior in different pathologies and correlation with severity of liver damage. METHODS: Circulating ICAM-1 and VCAM-1 were assayed by EIA commercial kits (R&D System Co., Abington, UK) in 23 patients with chronic active hepatitis (CH), 50 subjects affected by liver cirrhosis (LC) and 15 healthy controls comparable for sex and age. In patients, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were also detected by autoanalyzer. RESULTS: LC patients had significantly higher ICAM-1 values than CH patients (38.56±7.4 ng/mL vs20.89±6.42 ng/mL; P < 0.001) and these ones had significantly higher values than controls (12.92±1.08 ng/mL; P < 0.001). In CH group, ICAM-1 levels were significantly related to inflammatory activity (P= 0.041) and ALT values (r= 0.77; P < 0.05). VCAM-1 values were significantly increased only in LC patients (P < 0.001) and related to severity of liver impairment. CONCLUSION: These findings suggest that the determination of serum ICAM-1 can be considered as an additional useful marker of hepatocellular necrosis and inflammatory activity in chronic hepatitis, while serum VCAM-1 is an indicator of liver fibrogenesis and severity of disease in cirrhosis.
机译：目的：在炎症状态下，细胞间粘附分子-1（ICAM-1）和血管细胞粘附分子-1（VCAM-1）在促进免疫细胞从循环系统向靶位的迁移中起关键作用。我们研究的目的是研究病毒相关的慢性肝病患者中这些分子的可溶形式，以评估其在不同病理学中的行为以及与肝损害严重程度的相关性。方法：通过EIA商业试剂盒（英国阿宾顿R＆D System Co.）对23例慢性活动性肝炎（CH）患者，50例肝硬化（LC）患者和15例健康对照进行循环ICAM-1和VCAM-1测定性别和年龄相当。在患者中，还通过自动分析仪检测了血清丙氨酸转氨酶（ALT）和天冬氨酸转氨酶（AST）。结果：LC患者的ICAM-1值显着高于CH患者（38.56±7.4 ng / mL vs.20.89±6.42 ng / mL； P <0.001），而这些患者的ICAM-1值显着高于对照组（12.92±1.08 ng / mL）。 ; P <0.001）。在CH组，ICAM-1水平与炎症活动（P = 0.041）和ALT值（r = 0.77; P <0.05）显着相关。 VCAM-1值仅在LC患者中显着增加（P <0.001），并且与肝功能损害的严重程度有关。结论：这些发现表明，血清ICAM-1的测定可以被认为是慢性肝炎肝细胞坏死和炎症活动的另一个有用的标志物，而血清VCAM-1是肝纤维化和肝硬化疾病严重程度的指标。

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