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首页> 外文期刊>World Journal of Gastroenterology >Mutations in hepatitis B virus core regions correlate with hepatocellular injury in Chinese patients with chronic hepatitis B.
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Mutations in hepatitis B virus core regions correlate with hepatocellular injury in Chinese patients with chronic hepatitis B.

机译：乙型肝炎病毒核心区域的突变与中国慢性乙型肝炎患者的肝细胞损伤有关。

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摘要

AIM: To elucidate the relationship between the frequency of core mutations and the clinical activity of hepatitis B virus (HBV)-related liver disease and to characterize the amino acid changes in the core region of HBV. METHODS: We studied 17 Chinese patients with chronic hepatitis B according to their clinical courses and patterns of the entire core region of HBV. RESULTS: Amino acid changes often appeared in the HBV core region of the HBV gene in patients with high values of alanine aminotransferase (ALT) or with the seroconversion from HbeAg to anti-HBe. The HBV core region with amino acid changes had high frequency sites that corresponded to HLA I/II restricted recognition epitopes reported by some investigators. CONCLUSION: The core amino acid changes of this study occur due to influence of host immune system. The presence of mutations in the HBV core region seems to be important for predicting the clinical activity of hepatitis B in Chinese patients.
机译：目的：阐明核心突变的频率与乙型肝炎病毒（HBV）相关的肝病的临床活性之间的关系，并表征HBV核心区域的氨基酸变化。方法：我们根据临床过程和整个HBV核心区域的模式研究了17例中国慢性乙型肝炎患者。结果：丙氨酸氨基转移酶（ALT）值高或血清由HbeAg转为抗HBe的患者，HBV基因的HBV核心区域经常出现氨基酸变化。带有氨基酸变化的HBV核心区域具有高频位点，对应于一些研究者报道的HLA I / II限制性识别表位。结论：本研究的核心氨基酸变化是由于宿主免疫系统的影响而发生的。 HBV核心区突变的存在似乎对于预测中国患者乙型肝炎的临床活性很重要。

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