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首页> 外文期刊>World Journal of Gastroenterology >Intra-familial prevalence of hepatitis B virologic markers in HBsAg positive family members in Nahavand, Iran.
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Intra-familial prevalence of hepatitis B virologic markers in HBsAg positive family members in Nahavand, Iran.

机译：伊朗纳哈万德HBsAg阳性家庭成员中乙型肝炎病毒学标志物的家族内患病率。

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AIM: To determine the prevalence of hepatitis B in Nahavand and evaluate the HBsAg positive prevalence in families with a member who was confirmed to have HBV infection. METHODS: This study was performed in two phases. In the first phase, 1 824 subjects in Nahavand city were selected. The interviewers visited the houses of chosen families to fill the questionnaire and take the blood samples. All subjects signed an informed consent before interviews and blood sampling. The samples were evaluated for HBV virologic markers. In the second phase, 115 HBsAg-positive cases were enrolled and evaluated for HBV virologic markers. RESULTS: The prevalence of positive HBsAg in Nahavand was 2.3%. The most frequent relatives of index cases were sons and daughters (32.2% and 23.5% respectively). Twelve (11%) of all family members were HBsAg positive. Fifty (56.2%) were isolated HBsAb positive and only one person (2.5%) was isolated HBcAb positive. The higher rates of HBsAg marker were detected in the brothers (1-25%) and fathers (1-12.5%). The infection rate in husbands and wives of index cases was 10%. Only two (16.7%) of all HBsAg-positive participants reported previous HBV vaccination. CONCLUSION: The prevalence of intra-familial HBV infection is lower in Nahavand of Iran compared to other studies. More attention should be paid to HBV vaccination and risk-lowering activities.
机译：目的：确定在纳哈万德（Nahavand）的乙型肝炎患病率，并评估已确诊患有乙型肝炎病毒感染者的家庭中的乙肝表面抗原阳性率。方法：本研究分两个阶段进行。在第一阶段，选择了Nahavand市的1 824名受试者。访调员访问了选定家庭的房屋，以填写调查表并采集血液样本。所有受试者在访谈和采血前均签署知情同意书。评估样品的HBV病毒学标志。在第二阶段，招募了115例HBsAg阳性病例，并评估了HBV病毒学指标。结果：Nahavand HBsAg阳性的患病率为2.3％。索引病例的最亲戚是儿子和女儿（分别为32.2％和23.5％）。所有家庭成员中有十二（11％）人为HBsAg阳性。分离出的HBsAb阳性50例（56.2％），分离出的HBcAb阳性仅1人（2.5％）。兄弟（1-25％）和父亲（1-12.5％）的HBsAg标志物检出率较高。索引病例的丈夫和妻子的感染率为10％。所有HBsAg阳性参与者中只有两个（16.7％）报告过先前的HBV疫苗接种。结论：与其他研究相比，伊朗的纳哈万德家庭内HBV感染的患病率较低。应更加注意HBV疫苗接种和降低风险的活动。

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