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首页> 外文期刊>World Journal of Gastroenterology >Local recurrence is an important prognostic factor of hepatocellular carcinoma.
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Local recurrence is an important prognostic factor of hepatocellular carcinoma.

机译：局部复发是肝细胞癌的重要预后因素。

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AIM: To clarify the importance of complete treatment by PEIT. METHODS: A total of 140 previously untreated cases of HCC were enrolled in this study from 1988 to 2002. The inclusion criteria were: a solitary tumor less than 4 cm in diameter or multiple tumors, fewer than four in number and less than 3 cm in diameter, without extrahepatic metastasis or vessel invasion. As general principles for the treatment of HCC, the patients underwent transcatheter arterial chemoembolization (TACE) prior to PEIT. After the initial treatment of the patients, ultrasonography and computed tomography were performed, and measurement of serum levels of alpha-fetoprotein (AFP) was determined. When tumor recurrences were detected, PEIT and/or TACE were repeated whenever the hepatic functional reserve of the patient permitted. We then analyzed the variables that could influence prognosis, including tumor size and number, the serum levels of AFP, the parameters of hepatic function (albumin, bilirubin, ALT, hepaplastin test, platelet number, and indocyanine green retention at 15 min (ICG-R15)), combined therapy with TACE, distant recurrence, and local recurrence. RESULTS: Univariate analysis identified the ICG test, serum levels of AFP and albumin, tumor size and number, and local recurrence, but not distant recurrence, as significant prognostic variables. In multivariate analysis using those five parameters, the ICG test, tumor size, tumor number, and local recurrence were identified as significant prognostic factors. In both univariate and multivariate analyses, the relative risk for the ICG test was the highest, followed by local recurrence. CONCLUSION: We found that local recurrence is an independent prognostic factor of HCC, indicating that achieving complete treatment for HCC on first treatment is important for improving the prognosis of patients with HCC.
机译：目的：阐明PEIT完全治疗的重要性。方法：从1988年至2002年，共纳入140例先前未经治疗的HCC病例。纳入标准为：直径小于4 cm的孤立性肿瘤或多发性肿瘤，小于4例且小于3 cm。直径，无肝外转移或血管浸润。作为治疗HCC的一般原则，患者在PEIT之前先行经导管动脉化疗栓塞（TACE）。在对患者进行初步治疗后，进行了超声检查和计算机断层扫描，并测定了甲胎蛋白（AFP）的血清水平。当检测到肿瘤复发时，只要允许患者的肝功能储备，就重复PEIT和/或TACE。然后，我们分析了可能影响预后的变量，包括肿瘤的大小和数目，血清AFP的水平，肝功能的参数（白蛋白，胆红素，ALT，肝素检测，血小板数和15分钟时的吲哚菁绿保留）（ICG- R15）），TACE，远处复发和局部复发的联合治疗。结果：单因素分析确定ICG测试，血清AFP和白蛋白水平，肿瘤大小和数量以及局部复发而非远处复发是重要的预后变量。在使用这五个参数的多变量分析中，ICG测试，肿瘤大小，肿瘤数目和局部复发被确定为重要的预后因素。在单变量和多变量分析中，ICG测试的相对风险最高，其次是局部复发。结论：我们发现局部复发是肝癌的独立预后因素，表明在首次治疗时完成肝癌的完整治疗对改善肝癌患者的预后很重要。

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