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首页> 外文期刊>World Journal of Gastroenterology >Is adiponectin level a predictor of nonalcoholic fatty liver disease in nondiabetic male patients?
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Is adiponectin level a predictor of nonalcoholic fatty liver disease in nondiabetic male patients?

机译：脂联素水平是非糖尿病男性患者非酒精性脂肪肝疾病的预测指标吗？

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AIM: Adiponectin is a hepatic insulin sensitizer and also an inhibitor of tumor necrosis factor. We studied its levels in nondiabetic patients with nonalcoholic fatty liver disease (NAFLD) and compared with control group. METHODS: Thirty-five patients who had elevated serum aminotransferase levels with bright liver and 34 healthy volunteers without liver disease were evaluated. Age, gender and body mass index (BMI) were recorded. Fasting plasma glucose, insulin, adiponectin, proinsulin and lipid profile were measured. A standard oral glucose tolerance test (OGTT) with insulin response was performed and the index of insulin resistance was calculated according to the homeostasis model assessment (HOMA) method. RESULTS: According to the OGTT results, none of the participants had diabetes. Serum adiponectin levels were statistically significantly lower in patients with NAFLD than in control group (8.14+/-3.4 mug/mL vs 12.4+/-9.4 mug/mL, respectively, P<0.01). A statistically significant correlation was found between adiponectin and BMI (r : -0.33, P<0.01), HOMA (r : -0.26, P<0.05), proinsulin (r : -0.32, P<0.01), AST (r : -0.25, P<0.05), ALT (r : -0.26, P<0.05) or GGT (r : -0.22, P<0.05). In multiple regression analysis models, adiponectin levels were the only predictor of NAFLD in males, whereas in female group it was the BMI. CONCLUSION: Low adiponectin level might be a predictor of NAFLD especially in male nondiabetics.
机译：目的：脂联素是一种肝胰岛素增敏剂，也是肿瘤坏死因子的抑制剂。我们研究了非糖尿病性非酒精性脂肪性肝病（NAFLD）患者的血红素水平，并与对照组进行了比较。方法：评估了35例肝硬化患者血清氨基转移酶水平升高的患者和34例无肝病的健康志愿者。记录年龄，性别和体重指数（BMI）。测定空腹血糖，胰岛素，脂联素，胰岛素原和脂质分布。进行了具有胰岛素反应的标准口服葡萄糖耐量试验（OGTT），并根据稳态模型评估（HOMA）方法计算了胰岛素抵抗指数。结果：根据OGTT结果，没有参与者患有糖尿病。 NAFLD患者的血清脂联素水平在统计学上显着低于对照组（分别为8.14 +/- 3.4杯/毫升和12.4 +/- 9.4杯/毫升，P <0.01）。脂联素与BMI（r：-0.33，P <0.01），HOMA（r：-0.26，P <0.05），胰岛素原（r：-0.32，P <0.01），AST（r：- 0.25，P <0.05），ALT（r：-0.26，P <0.05）或GGT（r：-0.22，P <0.05）。在多元回归分析模型中，脂联素水平是男性NAFLD的唯一预测指标，而女性组是BMI。结论：脂联素水平低可能是NAFLD的预测指标，尤其是在男性非糖尿病患者中。

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