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首页> 外文期刊>World Journal of Gastroenterology >Hepatoprotective effects of Nigella sativa L and Urtica dioica L on lipid peroxidation, antioxidant enzyme systems and liver enzymes in carbon tetrachloride-treated rats.
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Hepatoprotective effects of Nigella sativa L and Urtica dioica L on lipid peroxidation, antioxidant enzyme systems and liver enzymes in carbon tetrachloride-treated rats.

机译：Nigella sativa L和Urtica dioica L对四氯化碳处理的大鼠脂质过氧化，抗氧化酶系统和肝酶的肝保护作用。

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AIM: To investigate the effects of Nigella sativa L (NS) and Urtica dioica L (UD) on lipid peroxidation, antioxidant enzyme systems and liver enzymes in CCl(4)-treated rats. METHODS: Fifty-six healthy male Wistar albino rats were used in this study. The rats were randomly allotted into one of the four experimental groups: A (CCl(4)-only treated), B (CCl(4)+UD treated), C (CCl(4)+NS treated) and D (CCl(4)+UD+NS treated), each containing 14 animals. All groups received CCl(4) (0.8 mL/kg of body weight, sc, twice a week for 60 d). In addition, B, C and D groups also received daily i.p. injections of 0.2 mL/kg NS or/and 2 mL/kg UD oils for 60 d. Group A, on the other hand, received only 2 mL/kg normal saline solution for 60 d. Blood samples for the biochemical analysis were taken by cardiac puncture from randomly chosen-seven rats in each treatment group at beginning and on the 60th d of the experiment. RESULTS: The CCl(4) treatment for 60 d increased the lipid peroxidation and liver enzymes, and also decreased the antioxidant enzyme levels. NS or UD treatment (alone or combination) for 60 d decreased the elevated lipid peroxidation and liver enzyme levels and also increased the reduced antioxidant enzyme levels. The weight of rats decreased in group A, and increased in groups B, C and D. CONCLUSION: NS and UD decrease the lipid per-oxidation and liver enzymes, and increase the anti-oxidant defense system activity in the CCl4-treated rats.
机译：目的：研究黑鬼菜（Nigella sativa L，NS）和荨麻（Urtica dioica L，UD）对CCl（4）处理的大鼠脂质过氧化，抗氧化酶系统和肝酶的影响。方法：本研究使用了56只健康的雄性Wistar白化病大鼠。将大鼠随机分配到四个实验组之一：A（仅CCl（4）处理），B（CCl（4）+ UD处理），C（CCl（4）+ NS处理）和D（CCl（4 4）+ UD + NS处理），每只包含14只动物。所有组均接受CCl（4）（0.8 mL / kg体重，皮下注射，每周两次，共60 d）。此外，B，C和D组也每天接受ip。注射0.2 mL / kg NS或/和2 mL / kg UD油60 d。另一方面，A组仅接受2 mL / kg生理盐溶液处理60天。在实验开始和实验的第60天，通过心脏穿刺从每个治疗组中随机选择的7只大鼠中采集用于生化分析的血液样品。结果：CCl（4）处理60 d可增加脂质过氧化和肝酶，并降低抗氧化酶水平。 NS或UD处理（单独或联合）治疗60 d可降低脂质过氧化和肝酶水平升高，同时还可降低抗氧化酶水平。结论：A组大鼠体重减轻，B组，C组和D组体重增加。结论：NS和UD降低了经CCl4处理的大鼠的脂质过氧化和肝酶，并增加了抗氧化防御系统的活性。

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