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Influences of Intraperitoneal Injection of Rare Earth Compounds on the Activities of Antioxidant Enzymes and the Level of Lipid Peroxidation in Mice Livers

机译:腹腔注射稀土化合物对小鼠肝脏抗氧化酶活性和脂质过氧化水平的影响

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Following intraperitoneal injection of lanthanum and terbium chloride and their complexes of diethyl triamino pentagacetic acid (DTPA) to adult mice with a dose of 0.28 mmol/kg body weight/day for three days. Respectively, the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) and the content of lipid end product, malonaldehyde (MDA) in the mice livers have been assayed. The results showed that the activity of SOD was increased and the content of MDA was reduced for LaCl_3 treated mice and the two targets were not changed for TbCl_3, but the activity of GSH-Px was reduced markedly for both LaCl_3 and TbCl_3 while above three targets were not changed for La-DTPA and Tb-DTPA complexes.
机译:以0.28 mmol / kg体重/天的剂量向成年小鼠腹膜内注射镧和氯化ter及其二乙基三氨基五乙酸(DTPA)的配合物三天。分别测定了小鼠肝脏中的超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)的活性以及脂质终产物丙二醛(MDA)的含量。结果表明,LaCl_3处理的小鼠的SOD活性增加,MDA的含量降低,而TbCl_3的两个靶点均未改变,但LaCl_3和TbCl_3的GSH-Px活性均显着降低,而三个靶点以上La-DTPA和Tb-DTPA配合物未改变。

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