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首页> 外文期刊>World Journal of Gastroenterology >Relative predictive factors for hepatocellular carcinoma after HBeAg seroconversion in HBV infection.
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Relative predictive factors for hepatocellular carcinoma after HBeAg seroconversion in HBV infection.

机译：HBV感染中HBeAg血清转化后肝细胞癌的相对预测因素。

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摘要

AIM: To determine the predictive factors for hepatocellular carcinoma (HCC) development in patients after spontaneous or therapeutic HBeAg seroconversion.METHODS: In 48 patients who seroconverted to anti-HBe positive during follow-up, the background factors for HCC development were analyzed.RESULTS: HCC was developed in six patients during follow-up (average follow-up after HBeAg seroconversion: 10.9+/-5.4 years). The incidence of HCC evaluated by Kaplan-Meier analysis was significantly higher in patients with abnormal aspartate aminotransferase (AST>40 IU/L) level, lower platelet counts (PLT< 10 x 10(4)/microL), lower albumin level (Alb<30 g/L), positive HBV-DNA or older age at seroconversion (>40 years). However, lower platelet count was the only predictive factor for HCC development shown by multivariate proportional-hazard analysis.CONCLUSION: Active hepatitis or advanced hepatitis at HBeAg seroconversion or progressive hepatitis even after HBeAg seroconversion would be the risk factors for HCC development. These predictive factors should be taken into account in determining the frequency of biochemical study or imaging studies for HCC surveillance.
机译：目的：确定自发或治疗性HBeAg血清转化后肝细胞癌（HCC）发生的预测因素方法：在随访过程中48例血清转化为抗HBe阳性的患者中，分析了HCC发生的背景因素。 ：在随访期间有6例患者发生了HCC（HBeAg血清转化后的平均随访时间：10.9 +/- 5.4年）。通过Kaplan-Meier分析评估的HCC发生率在天冬氨酸转氨酶异常（AST> 40 IU / L）水平，血小板计数较低（PLT <10 x 10（4）/ microL），白蛋白水平较低（Alb）的患者中明显更高<30 g / L），HBV-DNA阳性或血清转换时年龄较大（> 40岁）。然而，多因素比例风险分析显示，较低的血小板计数是肝癌发展的唯一预测因素。结论：即使是HBeAg血清转换的活动性肝炎或晚期肝炎，甚至在HBeAg血清转换后的进行性肝炎也将是发展HCC的危险因素。在确定用于HCC监测的生化研究或影像学研究的频率时，应考虑这些预测因素。

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