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首页> 外文会议>International Conference on Life Sciences and Technology >Computational Study of Betatrophin/ANGPTL8 and HBV Interaction on Lipoprotein Lipase Activity in The Development of Hepatocellular Carcinoma Caused by Metabolic syndrome-related HBV infection
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Computational Study of Betatrophin/ANGPTL8 and HBV Interaction on Lipoprotein Lipase Activity in The Development of Hepatocellular Carcinoma Caused by Metabolic syndrome-related HBV infection

机译：代谢综合征相关HBV感染引起肝细胞癌脂蛋白脂肪酶活性对脂蛋白脂酶活性的计算研究

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摘要

Hepatocellular carcinoma is cancer, which is a significant problem in several countries in the world, one of which is Indonesia. The presence of hepatocellular carcinoma is often accompanied by the occurrence of the metabolic syndrome and infection of the HBV virus. Lipoprotein lipase (LPL) is an enzyme that is thought to be a key factor of metabolic syndrome occurrence and also HBV infection. This computational study aims to see the interaction between ANGPTL8 and HBV virus particles against LPL as a target. Our study shows that HBV and ANGPTL8 have different binding regions in the LPL enzyme so that they can bind simultaneously. Computationally HBV has stronger energy bonds than ANGPTL8. To sum up, this study can be the hallmark of another research to find out the role of LPL in the occurrence of Hepatocellular carcinoma by the binding of ANGPTL8 and HBV.
机译：肝细胞癌是癌症，这是世界上几个国家的重大问题，其中一个是印度尼西亚。 肝细胞癌的存在通常伴随着代谢综合征和HBV病毒感染的发生。 脂蛋白脂肪酶（LPL）是一种酶，被认为是代谢综合征发生和HBV感染的关键因素。 该计算研究旨在在AngptL8和HBV病毒颗粒对LPL作为靶标之间的相互作用。 我们的研究表明，HBV和Angpt18在LPL酶中具有不同的结合区域，使得它们可以同时结合。 计算上的HBV具有比AngptL8更强的能量键。 总而言之，这项研究可以是另一个研究的标志，以通过Angptl8和HBV的结合发现LPL在肝细胞癌发生中的作用。

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