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首页> 外文期刊>World Journal of Gastroenterology >Computer-aided morphometry of liver inflammation in needle biopsies.
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Computer-aided morphometry of liver inflammation in needle biopsies.

机译：针刺活检中肝脏炎症的计算机辅助形态分析。

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AIM:To introduce a computer-aided morphometric method for quantifying the necro-inflammatory phase in liver biopsy specimens using fractal geometry and Delaunay's triangulation.METHODS:Two-micrometer thick biopsy sections taken from 78 chronic hepatitis C virus-infected patients were immunohistochemically treated to identify the inflammatory cells. An automatic computer-aided image analysis system was used to define the inflammatory cell network defined on the basis of Delaunay's triangulation, and the inflammatory cells were geometrically classified as forming a cluster (an aggregation of a minimum of three cells) or as being irregularly distributed within the tissue. The phase of inflammatory activity was estimated using Hurst's exponent.RESULTS:The proposed automatic method was rapid and objective. It could not only provide rigorous results expressed by scalar numbers, but also allow the state of the whole organ to be represented by Hurst's exponent with an error of no more than 12%.CONCLUSION:The availability of rigorous metrical measures and the reasonable representativeness of the status of the organ as a whole raise the question as to whether the indication for hepatic biopsy should be revised by establishing clear rules concerning the contraindications suggested by its invasiveness and subjective interpretation.
机译：目的：介绍一种计算机辅助形态计量学方法，以分形几何和Delaunay三角测量法定量肝活检标本中的坏死性炎症阶段。方法：对78例慢性丙型肝炎病毒感染患者的两微米厚活检切片进行免疫组织化学处理鉴别炎性细胞。使用自动计算机辅助图像分析系统来定义根据Delaunay三角剖分定义的炎症细胞网络，并且将炎症细胞在几何上分类为形成簇（至少三个细胞的聚集）或不规则分布在组织内。结果：所提出的自动方法快速，客观。它不仅可以提供标量数字表示的严格结果，而且可以使整个器官的状态用赫斯特指数来表示，误差不超过12％。结论：采用严格的度量标准并具有合理的代表性整个器官的状况提出了一个问题，即是否应通过针对其侵入性和主观解释所建议的禁忌症制定明确的规则来修改肝活检的指征。

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