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首页> 外文期刊>World Journal of Gastroenterology >Nuclear and mitochondrial DNA microsatellite instability in hepatocellular carcinoma in Chinese
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Nuclear and mitochondrial DNA microsatellite instability in hepatocellular carcinoma in Chinese

机译：肝细胞癌的核和线粒体DNA微卫星不稳定性

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AIM: To study the nuclear microsatellite instability (nMSI) at BAT26 and mitochondral microsalellite instability (mtMSI) in the occurrence and development of hepatocellular carcinoma and the relationship between nMSI and mtMSI. METHODS: nMSI was observed with PCR and mtMSI with PCR-SSCP in 52 cases of hepatocellular carcinoma. RESULTS: mtMSI was detected in 11 out of the 52 cases of hepatocellular carcinoma (21.2%). Among the 11 cases of hepatocellular carcinoma with mtMSI, 7 occured in one locus and 4 in 2 loci. The frequency of mtMSI in the 52 cases of hepatocellular carcinoma showed no correlation to sex, age, infection of hepatitis B, liver cirrhosis as well as positive AFP of the patients (P > 0.05). In addition, nMSI was detected in 3 out of 52 cases of hepatocellular carcinoma (5.8%) and there was no correlation of the incidence of mtMSI to that of nMSI (P>0.05). CONCLUSION: mtMSI may be involved in the coccurrence and development of hepatocellular carcinoma and it is independent of nMSI.
机译：目的：研究肝细胞癌发生发展过程中BAT26核微卫星不稳定性（nMSI）和线粒体微卫星不稳定性（mtMSI）及其与nMSI和mtMSI之间的关系。方法：对52例肝细胞癌采用nMSI进行PCR检测，对mtMSI进行PCR-SSCP检测。结果：52例肝细胞癌中有11例检出mtMSI（21.2％）。在11例带有mtMSI的肝细胞癌病例中，有7个发生在一个位点，4个发生在2个位点。 52例肝细胞癌中mtMSI的发生频率与患者的性别，年龄，乙型肝炎感染，肝硬化以及AFP阳性无关（P> 0.05）。另外，在52例肝细胞癌中有3例检测到nMSI（5.8％），并且mtMSI的发生与nMSI的发生没有相关性（P> 0.05）。结论：mtMSI可能与肝细胞癌的发生，发展有关，与nMSI无关。

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