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首页> 外文期刊>World Journal of Gastroenterology >Expression of platelet-derived growth factor-BB in liver tissues of patients with chronic hepatitis B
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Expression of platelet-derived growth factor-BB in liver tissues of patients with chronic hepatitis B

机译：慢性乙型肝炎患者肝组织中血小板衍生生长因子-BB的表达

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AIM: To study the relationship between expression of platelet-derived growth factor-BB (PDGF-BB) and fibrogenesis in chronic hepatitis B. METHODS: Hepatic tissues from 43 patients with chronic hepatitis B were embedded in paraffin. The sections were stained with HE and picric acid-sirius red to determine inflammatory activity and fibrosis stages. PDGF-BB expression was detected by immunohistochemistry and assessed semiquantatively. Levels of serum hyaluronic acid (HA), pro-collagen Ⅲ (PCⅢ), collagen Ⅳ (Ⅳ-C) and laminin (LN) were examined by radioimmunoassay (RIA). RESULTS: The expression level of PDGF-BB was found to be positively correlated with inflammatory activity, fibrosis stage and grade of histological findings (τ=0.58, 0.55, 0.55, P<0.01). The positive correlation was also observed between tissue level of PDGF-BB expression and contents of HA, PCⅢ, Ⅳ-C and LN in the circulation (r=0.52, 0.32, 0.40, 0.33, P<0.05). CONCLUSION: PDGF-BB may play some role in the development and progression of liver fibrosis.
机译：目的：探讨慢性乙型肝炎患者血小板衍生生长因子-BB（PDGF-BB）的表达与纤维化的关系。方法：将43例慢性乙型肝炎患者的肝组织包埋在石蜡中。将切片用HE和苦味酸-天狼星红染色以确定炎症活性和纤维化阶段。通过免疫组织化学检测PDGF-BB的表达并进行半定量评估。用放射免疫法（RIA）检测血清透明质酸（HA），Ⅲ型胶原（PCⅢ），Ⅳ型胶原（Ⅳ-C）和层粘连蛋白（LN）的水平。结果：PDGF-BB的表达水平与炎症活性，纤维化分期和组织学分级呈正相关（τ= 0.58，0.55，0.55，P <0.01）。 PDGF-BB的表达水平与血液中HA，PCⅢ，Ⅳ-C和LN的含量也呈正相关（r = 0.52、0.32、0.40、0.33，P <0.05）。结论：PDGF-BB可能在肝纤维化的发生发展中起一定作用。

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