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首页> 外文期刊>World Journal of Gastroenterology >Risk factors of development of gut-derived bacterial translocation in thermally injured rats
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Risk factors of development of gut-derived bacterial translocation in thermally injured rats

机译：热损伤大鼠肠道源性细菌易位发展的危险因素

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AIM: Studies have demonstrated that gut-derived bacterial translocation (BT) might play a role in the occurrence of sepsis and multiple organ dysfunction syndrome (MODS). Yet, no convincing overall analysis of risk factors for BT has been reported. The purpose of this study was to evaluate the related factors for the development of BT in burned rats. METHODS: Wistar rats were subjected to 30% third-degree burns. Then samples were taken on postburn d 1, 3, and 5. Incidence of BT and counts of mucosal bifidobacteria, fungi and E. coli, mucus sIgA, degree of injury to ileal mucosa, and plasma interleukin-6 were observed. Univariate analysis and multivariate logistic regression analysis were performed. RESULTS: The overall BT rate was 53.9% (69 in 128). The result of univariate analysis showed that the levels of plasma endotoxin and interleukin-6, the counts of mucosal fungi and E. coli, and the scores of ileum lesion were markedly increased in animals with BT compared with those without (P=0.000-0.005), while the levels of mucus sIgA and the counts of mucosal bifidobacteria were significantly reduced in animals with translocation compared with those without (P=0.000). There was a significant positive correlation between mucus sIgA and the counts of mucosal bifidobacteria (r=0.74, P=0.001). Moreover, there were strong negative correlations between scores of ileum-lesion and counts of bifidobacteria (r=-0.67, P=0.00.1). Multivariate logistic regression revealed that ileum lesion score (odds ratio [OR] 45.52, 95% confidence interval [CI] 5.25-394.80), and counts of mucosal bifidobacteria (OR 0.039, 95% CI 0.0032-0.48) were independent predictors of BT secondary to severe burns. CONCLUSION: Ileal lesion score and counts of mucosal bifidobacteria can be chosen as independent prognosis factors of the development of BT. Specific interventions targeting these high-risk factors might be implemented to attenuate BT, including strategies for repair of damaged intestinal mucosae and restoration of the balance of gastrointestinal flora.
机译：目的：研究表明肠源性细菌易位（BT）可能在败血症和多器官功能障碍综合症（MODS）的发生中起作用。然而，尚未有令人信服的BT危险因素全面分析报告。这项研究的目的是评估烧伤大鼠中BT发展的相关因素。方法：Wistar大鼠遭受30％的三度烧伤。然后在烧伤后第1、3和5天取样。观察BT的发生率以及粘膜双歧杆菌，真菌和大肠杆菌，粘液sIgA，回肠粘膜的损伤程度以及血浆白介素6的计数。进行单因素分析和多元逻辑回归分析。结果：总体BT率为53.9％（128中为69）。单因素分析的结果表明，与不使用BT的动物相比，使用BT的动物的血浆内毒素和白细胞介素6的水平，粘膜真菌和大肠杆菌的计数以及回肠病变的分数显着增加（P = 0.000-0.005 ），而易位动物的粘液sIgA水平和粘膜双歧杆菌的计数与未转位的动物相比明显降低（P = 0.000）。粘液sIgA与粘膜双歧杆菌计数之间存在显着正相关（r = 0.74，P = 0.001）。此外，回肠病变评分与双歧杆菌计数之间存在极强的负相关性（r = -0.67，P = 0.00.1）。多因素logistic回归分析显示回肠病变评分（比值比[OR] 45.52，95％置信区间[CI] 5.25-394.80）和粘膜双歧杆菌计数（OR 0.039，95％CI 0.0032-0.48）是BT继发性疾病的独立预测因子严重烧伤。结论：回肠病变评分和粘膜双歧杆菌计数可作为BT发展的独立预后因素。针对这些高危因素的特殊干预措施可能会实施以减轻BT，包括修复受损肠粘膜和恢复胃肠道菌群平衡的策略。

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