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首页> 外文期刊>World Journal of Gastroenterology >Brain metastasis of hepatocellular carcinoma: A case report and review of the literature
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Brain metastasis of hepatocellular carcinoma: A case report and review of the literature

机译：肝细胞癌的脑转移：一例报告并文献复习

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摘要

Hepatocellular carcinoma (HCC) is one of the most frequent malignancies in the world. It is more common in far eastern countries and relatively rare in the United States and western European countries where at autopsy it accounts for only 1-2% of malignant tumors. The disease is usually manifested in the the 6th and 7th decade of life. HCC is one of the highly malignant neoplasms. Extrahepatic metastases are seen in 64% of patients with HCC. The lungs, regional lymph nodes, kidney, bone marrow and adrenals are common sites of HCC metastasis. But, metastasis to brain and skull is extremely rare. Table 1 shows some of the reported cases of HCC with brain metastasis. These case reports reaffirms the complex and multidisciplinary care of these patients. The interval between diagnosis of primary cancer and detection of brain metastasis ranged from 2 to 54 mo. The mean survival period was only 3 mo after diagnosis of brain metastasis. The patients with HCC metastasized to brain died of neurologic causes rather than hepatic failure. Although no treatment is clearly defined to increase survival in patients with unresectable tumors, early diagnosis could improve the chance of curative surgical resection. We describe a case of HCC presenting with the initial manifestations of an intracranial mass lesion without any symptoms or signs suggestive of the primary hepatic site of the tumor. The diagnosis could not be made until he was admitted to hospital with unilateral weakness and numbness.
机译：肝细胞癌（HCC）是世界上最常见的恶性肿瘤之一。它在远东国家中更为常见，在美国和西欧国家中相对较少，在尸体解剖时，它仅占恶性肿瘤的1-2％。该病通常表现在生命的第六和第七个十年。肝癌是高度恶性的肿瘤之一。在64％的HCC患者中可见肝外转移。肺，局部淋巴结，肾脏，骨髓和肾上腺是肝癌转移的常见部位。但是，转移至大脑和颅骨的情况极为罕见。表1显示了一些报告的伴有脑转移的HCC病例。这些病例报告重申了这些患者的复杂和多学科护理。诊断原发癌与检测脑转移之间的间隔为2到54 mo。诊断为脑转移后，平均生存期仅为3 mo。转移到大脑的HCC患者死于神经系统原因而不是肝衰竭。尽管没有明确定义可以增加不可切除肿瘤患者生存率的治疗方法，但早期诊断可以提高治愈性手术切除的机会。我们描述了一种HCC病例，其表现为颅内肿块病变的初始表现，没有任何暗示该肿瘤原发性肝部位的症状或体征。在他因单方面无力和麻木入院之前，无法做出诊断。

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