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首页> 外文期刊>World Journal of Gastroenterology >CDw75 is a significant histopathological marker for gastric carcinoma
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CDw75 is a significant histopathological marker for gastric carcinoma

机译：CDw75是胃癌的重要组织病理学指标

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AIM: To study the expression of CDw75 in patients with gastric carcinoma and to correlate CDw75 expression with progression of the tumor. METHODS: Immunohistochemical method was used to examine the expression of CDw75 in 72 cases of the gastric carcinoma and adjacent normal gastric mucosa, and the percentage of the cells positively stained with CDw75 was calculated using a computer-aided microscopic image analysis system. RESULTS: CDw75 was not expressed in normal gastric mucosa but detected in 37 of the 72 neoplastic gastric lesions. The expression of CDw75 was associated with the tumor progression as indicated by its close correlation with the depth of the tumor infiltration (χ~2= 18.415, P<0.01), TNM stage (χ~2=10.419, P<0.05) and lymph node metastasis (χ~2=6.675, P<0.01). The overall survival rate of the patients with positive CDw75 expression (32.4%) was significantly lower than that of the patients without CDw75 expression (71.4%) (P<0.01). There was no significant correlation between the expression of CDw75 and the sex and age and histological type of patients (P>0.05). CONCLUSION: These findings suggest that the expression of CDw75 is a significant histopathological marker for more advanced stage of gastric carcinoma and indicates a poor prognosis for the patients.
机译：目的：研究CDw75在胃癌患者中的表达，并将CDw75的表达与肿瘤的进展相关联。方法：采用免疫组织化学方法检测72例胃癌及邻近正常胃黏膜中CDw75的表达，并用计算机显微镜图像分析系统计算CDw75阳性染色的细胞百分比。结果：CDw75在正常胃粘膜中不表达，但在72例肿瘤性胃病灶中有37例被检测到。 CDw75的表达与肿瘤的进展有关，这与肿瘤的浸润深度（χ〜2 = 18.415，P <0.01），TNM分期（χ〜2 = 10.419，P <0.05）和淋巴结密切相关。淋巴结转移（χ〜2 = 6.675，P <0.01）。 CDw75阳性的患者的总生存率（32.4％）明显低于CDw75阳性的患者（71.4％）（P <0.01）。 CDw75的表达与患者的性别，年龄和组织学类型之间无显着相关性（P> 0.05）。结论：这些发现表明CDw75的表达是胃癌晚期的重要组织病理学标志，并预示了患者的不良预后。

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