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首页> 外文期刊>World Journal of Gastroenterology >Relationship between microvessel density and telomerase activity in hepatocellular carcinoma
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Relationship between microvessel density and telomerase activity in hepatocellular carcinoma

机译：肝细胞癌中微血管密度与端粒酶活性的关系

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AIM: To study the relationship between microvessel density (MVD), telomerase activity and biological characteristics in hepatocellular carcinoma (HCC). METHODS: S-P immunohistochemical method and telomeric repeat amplification protocol (TRAP) were respectively used to analyze the MVD and telomerase activity in 58 HCC and adjacent normal tissues. RESULTS: The MVD in HCC with metastasis, lower differentiation or without intact capsule was significantly higher than that in HCC with intact capsule, higher differentiation, or without metastasis. While MVD had no relationship with tumor size, hepatic virus infection and other clinical factors. Telomerase activity was related to differentiation degree, but not to tumor size or histological grade. MVD in HCC with telomerase activity was higher than that in HCC without telomerase activity. CONCLUSION: MVD and telomerase activity may serve as diagnostic criteria of HCC in earlier stage. Meanwhile, there may be a cooperative effect between MVD and telomerase on the growth and metastasis of HCC.
机译：目的：研究肝细胞癌（HCC）中微血管密度（MVD），端粒酶活性与生物学特性之间的关系。方法：采用S-P免疫组化法和端粒重复扩增法（TRAP）分别分析58例肝癌及癌旁正常组织的MVD和端粒酶活性。结果：伴有转移，分化程度低或不伴有完整包膜的肝癌的MVD显着高于带伴有完整胶囊，分化程度高或未伴有转移的肝癌的MVD。 MVD与肿瘤大小，肝病毒感染和其他临床因素无关。端粒酶活性与分化程度有关，而与肿瘤大小或组织学等级无关。具有端粒酶活性的肝癌患者的MVD高于无端粒酶活性的肝癌患者的MVD。结论：MVD和端粒酶活性可作为早期肝癌的诊断标准。同时，MVD和端粒酶可能对肝癌的生长和转移有协同作用。

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