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首页> 外文期刊>World Journal of Gastroenterology >Changes of gutflora and endotoxin in ratswith D-galactosamine-induoed acute liver failure
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Changes of gutflora and endotoxin in ratswith D-galactosamine-induoed acute liver failure

机译：D-半乳糖胺诱发的急性肝衰竭大鼠肠道菌群和内毒素的变化

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AIM: To investigate the changes of gut microflora and endotoxin levels in rats with acute liver failure (ALF) induced by D-galactosamine (GaIN). METHODS: Flora and endotoxin levels in the jejunum, ileum and colon in normal rats (group A) and rats with GaIN -induced ALF were determined at 24 h (group B) or 48 h (group C) after GaIN injection, as well as the endotoxin level in portal venous blood (PVB) and right ventricle blood (RVB) were determined by chromogenic limulus amoebocyte assay. RESULTS: Intestinal (jejunum, ileum, colon) lactobacillus count was statistically reduced in group B compared with those in group A (3.4+-0.3 vs 4.9+-0.3, 6.1+-0.4 vs 8.0+-0.3, 8.1+-0.2 vs 9.3+-0.2, P<0.001, P<0.001 and P<0.001 respectively) and recovered partially in the group C compared with those in the group B, whereas the count of Enterobacteriaceae in the jejunum, ileum and colon in group B was increased markedly compared with those in the group A (5.1+-0.3 vs 3.6+-0.2, 6.9+-0.5 vs 5.3+-0.3, 8.7+-0.2 vs 7.6+-0.1, P<0.001, P<0.05 and P<0.05 respectively) and restored partially in the group C compared with those in the group B. The endotoxin level in ileum was increased in the group B compared with those in the group A (111.3+-22.8 vs 51.5+-8.9, P<0.05). In addition, the endotoxin level in PVB was obviously increased in group Bcompared with that in the group A (76.8+-9.1 vs 40.6+-7.3, P<0.01) and reduced to the baseline at 48 h (group C). CONCLUSION: Severely disturbed gut flora in rats with GalN-induced acute liver failure plays an important role in the elevation of endotoxin level in PVB.
机译：目的：探讨D-半乳糖胺（GaIN）引起的急性肝衰竭（ALF）大鼠肠道菌群和内毒素水平的变化。方法：在注射GaIN后24小时（B组）或48小时（C组）测定正常大鼠（A组）和GaIN诱导的ALF大鼠空肠，回肠和结肠中的菌群和内毒素水平，以及通过显色lim变形细胞测定法测定门静脉血（PVB）和右心室血（RVB）的内毒素水平。结果：与A组相比，B组的肠道（空肠，回肠，结肠）乳酸杆菌计数明显降低（3.4 + -0.3 vs 4.9 + -0.3、6.1 + -0.4 vs 8.0 + -0.3、8.1 + -0.2 vs与B组相比，C组的9.3 + -0.2，P <0.001，P <0.001和P <0.001）和部分恢复，而B组的空肠，回肠和结肠的肠杆菌科计数增加与A组相比有显着差异（5.1 + -0.3 vs 3.6 + -0.2、6.9 + -0.5 vs 5.3 + -0.3、8.7 + -0.2 vs 7.6 + -0.1，P <0.001，P <0.05和P <0.05 C组的回肠内毒素水平与A组相比有所增加（111.3 + -22.8 vs 51.5 + -8.9，P <0.05） 。此外，与A组相比，B组PVB中的内毒素水平明显升高（76.8 + -9.1 vs 40.6 + -7.3，P <0.01），并在48 h（C组）降至基线。结论：GalN诱导的急性肝衰竭大鼠肠道菌群严重紊乱在PVB内毒素水平升高中起重要作用。

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