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首页> 外文期刊>World Journal of Gastroenterology >An unusual presentation of 'silent' disseminated pancreatic neuroendocrine tumor
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An unusual presentation of 'silent' disseminated pancreatic neuroendocrine tumor

机译：“沉默的”弥漫性胰腺神经内分泌肿瘤的异常表现

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摘要

To present a patient diagnosed with pancreatic carcinoid that was extremely rare and produced an atypical carcinoid syndrome. We reported a 58-year old male patient who presented with long standing, prominent cervical lymphadenopathy and occasional watery diarrhea. Pathohistological and immunohistochemical examination of lymph node biopsy showed a metastatic neuroendocrine tumor, which was histological type A of carcinoid (EMA+, cytokeratin+, CEA-, NSE+, chromogranin A+, synaptophysin+, insulin-). Bone marrow biopsy showed identical findings. Primary site of the tumor was pancreas and diagnosis was made according to cytological and immunocytochemical analysis of the tumor cells obtained with aspiration biopsy of pancreatic mass (12 mm in diameter) under endoscopic ultrasound guidance. However, serotonin levels in blood and urine samples were normal. It is difficulty to establish the precise diagnosis of a "functionally inactive" pancreatic carcinoid and aspiration biopsy of pancreatic tumor under endoscopic ultrasound guidance can be used as a new potent diagnostic tool.
机译：介绍一个被诊断患有胰腺类癌的患者，这种患者极为罕见并产生非典型类癌综合征。我们报道了一位58岁的男性患者，其长期站立，突出的颈淋巴结病和偶尔的水样腹泻。淋巴结活检的病理组织学和免疫组织化学检查显示有转移性神经内分泌肿瘤，是类癌的组织学类型A（EMA +，细胞角蛋白+，CEA-，NSE +，嗜铬粒蛋白A +，突触素+，胰岛素-）。骨髓活检显示相同的发现。肿瘤的主要部位是胰腺，并根据在内镜超声引导下通过胰腺肿物（直径12 mm）的穿刺活检获得的肿瘤细胞的细胞学和免疫细胞化学分析进行诊断。但是，血液和尿液样本中的血清素水平是正常的。建立“功能失活”的胰腺类癌的精确诊断是困难的，在内镜超声引导下进行胰腺肿瘤穿刺活检可作为一种新的有效诊断工具。

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