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首页> 外文期刊>World Journal of Gastroenterology >Are gap junction gene connexins 26,32 and 43 of prognostic values in hepatocellular carcinoma? A prospective study
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Are gap junction gene connexins 26,32 and 43 of prognostic values in hepatocellular carcinoma? A prospective study

机译：间隙连接基因连接蛋白在肝细胞癌中的预后价值为26、32和43吗？前瞻性研究

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摘要

AIM: To investigate the prognostic value of the expression of connexin (Cx) 26, 32 and 43 messenger RNA (mRNA) in hepatocellular carcinoma (HCC) tissues. METHODS: Using a reverse-transcriptase polymerase chain reaction (RT-PCR), Cx 26, Cx 32 and Cx 43 mRNAs were determined in the liver tissues of 15 controls and in HCC tissues of 25 patients undergoing curative hepatic resection. The patients were followed up clinically. RESULTS: Cx 26 and Cx 32 mRNAs were significantly tower in HCC tissues compared with controls (both P< 0.01). By multivariate analysis, a lower level of Cx 26 and Cx 32 mRNA correlated significantly with a risk of HCC recurrence (P= 0.033) and recurrence-related mortality (P= 0.031, P= 0.031). Cx 43 mRNA was higher in HCC tissues compared with controls but did not correlate with postoperative recurrence or recurrence-related mortality. Other significant predictors of HCC recurrence included cellular dedifferentiation (P = 0.033), less encapsulation (P = 0.050), vascular permeation (P= 0.046), and daughter nodules (P= 0.046). Significant variables related to recurrence-related mortality consisted of cell dedifferentiation (P= 0.031), vascular permeation (P= 0.048), and daughter nodules (P= 0.048). The levels of Cx 26 and Cx 32 mRNAs correlated significantly with cell differentiation (P= 0.031). CONCLUSION: A low expression of Cx 26 and Cx 32 mRNAs in HCC tissues is predictive of postoperative recurrence of HCCs.
机译：目的：探讨连接蛋白（Cx）26、32和43信使RNA（mRNA）在肝细胞癌（HCC）组织中表达的预后价值。方法：使用逆转录聚合酶链反应（RT-PCR），在15例对照肝组织和25例行根治性肝切除术的HCC组织中测定了Cx 26，Cx 32和Cx 43 mRNA。对患者进行临床随访。结果：与对照组相比，肝癌组织中Cx 26和Cx 32 mRNA显着升高（均P <0.01）。通过多变量分析，较低水平的Cx 26和Cx 32 mRNA与HCC复发风险（P = 0.033）和与复发相关的死亡率（P = 0.031，P = 0.031）显着相关。与对照组相比，HCC组织中的Cx 43 mRNA较高，但与术后复发或与复发相关的死亡率无关。 HCC复发的其他​​重要预测指标包括细胞脱分化（P = 0.033），包囊减少（P = 0.050），血管渗透（P = 0.046）和子结节（P = 0.046）。与复发相关死亡率相关的重要变量包括细胞去分化（P = 0.031），血管渗透（P = 0.048）和子结节（P = 0.048）。 Cx 26和Cx 32 mRNA的水平与细胞分化显着相关（P = 0.031）。结论：肝癌组织中Cx 26和Cx 32 mRNA的低表达可预示肝癌术后复发。

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