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首页> 外文期刊>World Journal of Gastroenterology >Correlation between expression of cyclooxygenase-2 and angiogenesis in human gastric adenocarcinoma
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Correlation between expression of cyclooxygenase-2 and angiogenesis in human gastric adenocarcinoma

机译：人胃腺癌中环氧合酶-2的表达与血管生成的关系

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AIM: To evaluate the expression of cyclooxygenase (COX-2) and the relationship with tumor angiogenesis and advancement in gastric adenocarcinoma. METHODS: Immunohistochemical stain was used for detecting the expression of COX-2 in 45 resected specimens of gastric adenocarcinoma; the monoclonal antibody against CD34 was used for displaying vascular endothelial cells, and microvascular density (MVD) was detected by counting of CD34-positive vascular endothelial cells. Paracancerous tissues were examined as control. RESULTS: Immunohistological staining with COX-2-specific polyclonal antibody showed cytoplasmic staining in the cancer cells, some atypical hyperplasia and intestinal metaplasia, as well as angiogenic vasculature present within the tumors and prexisting vasculature adjacent to cancer lesions. The rate of expression of COX-2 and MVD index in gastric cancers were significantly increased, compared with those in the paracancerous tissues (77.78 vs 33.33 %, 58.13+-19.99 vs 24.02+-10.28, P<0.01, P<0.05, respectively). In 36 gastric carcinoma specimens with lymph node metastasis, the rate of COX-2 expression and MVD were higher than those in the specimens without metostasis (86.11 vs 44.44 %, 58.60+-18.24 vs 43.54+-15.05, P<0.05, P<0.05, respectively). The rate of COX-2 expression and MVD in the specimens with invasive serosa were significantly higher than those in the specimens without invasion to serosa (87.88 vs 50.0 %, 57.01+-18.79 vs 42.35+-14.65, P<0.05, P<0.05). Moreover, MVD in COX-2-positive specimens was higher than that in COX-2-negative specimens (61.29+-14.31 vs 45.38+-12.42, P<0.05). COX-2 expression was positively correlated with MVD (r=0.63, P<0.05). CONCLUSION: COX-2 expression might correlate with the occurance and advancement of gastric carcinoma and is involved in tumor angiogenesis in gastric carcinoma. It is likely that COX-2 by inducing angiogenesis can be one of mechanisms which promotes invasion and metastasis of gastric carcinoma. It may become a new therapeutic target for anti-angiogenesis.
机译：目的：探讨环氧合酶（COX-2）的表达及其与胃腺癌肿瘤血管生成和进展的关系。方法：采用免疫组织化学染色法检测45例切除的胃腺癌组织中COX-2的表达。使用针对CD34的单克隆抗体展示血管内皮细胞，并通过计数CD34阳性血管内皮细胞来检测微血管密度（MVD）。检查癌旁组织作为对照。结果：COX-2特异性多克隆抗体免疫组织学染色显示癌细胞胞浆染色，一些非典型增生和肠化生以及肿瘤内存在的血管生成性脉管和与癌病灶相邻的先存在的脉管。与癌旁组织相比，胃癌中COX-2和MVD指数的表达率显着增加（分别为77.78％和33.33％，58.13 + -19.99％和24.02 + -10.28，P <0.01，P <0.05 ）。在36例具有淋巴结转移的胃癌标本中，COX-2表达和MVD的发生率均高于未发生过转移的标本（86.11 vs 44.44％，58.60 + -18.24 vs 43.54 + -15.05，P <0.05，P < 0.05）。浸润性浆膜样本中COX-2表达和MVD的发生率明显高于未浸润性浆膜样本（87.88 vs 50.0％，57.01 + -18.79 vs 42.35 + -14.65，P <0.05，P <0.05 ）。此外，COX-2阳性标本的MVD高于COX-2阴性标本的MVD（61.29 + -14.31 vs 45.38 + -12.42，P <0.05）。 COX-2表达与MVD呈正相关（r = 0.63，P <0.05）。结论：COX-2表达可能与胃癌的发生发展有关，并参与胃癌的肿瘤血管生成。通过诱导血管生成的COX-2可能是促进胃癌浸润和转移的机制之一。它可能成为抗血管生成的新治疗靶标。

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